Epiprednisolone

Base Information Edit

Chemical Name:Epiprednisolone
CAS No.:600-90-8
Molecular Formula:C21H28O5
Molecular Weight:360.45
Hs Code.:
UNII:VC7U8F7FXE
Nikkaji Number:J1.500.587D
Mol file:600-90-8.mol

Synonyms:Epiprednisolone;600-90-8;11-epi-Prednisolone;VC7U8F7FXE;UNII-VC7U8F7FXE;Prednisolone impurity F [EP];11alpha,17,21-Trihydroxypregna-1,4-diene-3,20-dione;(8S,9S,10R,11R,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one;(11alpha)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione;Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11alpha)-;SCHEMBL6566835;PREDNISOLONE IMPURITY F [EP IMPURITY];E80413;11.ALPHA.,17,21-TRIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE;(11.ALPHA.)-11,17,21-TRIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE;PREGNA-1,4-DIENE-3,20-DIONE, 11,17,21-TRIHYDROXY-, (11.ALPHA.)-

Suppliers and Price of Epiprednisolone

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
11-epi-Prednisolone
5mg
$ 1540.00

Medical Isotopes, Inc.
Epiprednisolone
10 mg
$ 650.00

Total 13 raw suppliers

Chemical Property of Epiprednisolone Edit

Chemical Property:

Melting Point:222-223 °C
Boiling Point:570.6±50.0 °C(Predicted)
PKA:12.46±0.70(Predicted)
PSA：94.83000
Density:1.31±0.1 g/cm3(Predicted)
LogP:1.55760
Storage Temp.:-20°C Freezer
Solubility.:Acetonitrile (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly,
XLogP3:1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:360.19367399
Heavy Atom Count:26
Complexity:724

Purity/Quality:

99%, ^*data from raw suppliers

11-epi-Prednisolone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC12CC(C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C)O
Isomeric SMILES:C[C@]12C[C@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C)O
Recent EU Clinical Trials:A Phase 2a Randomised, Double Blind, Multi-centre Study to Assess the Effect on Glucose Homeostasis of Two Dose Levels of AZD9567, Compared to Prednisolone, in Adults with Type 2 Diabetes
Uses Epiprednisolone is a derivative of prednisolone (P703740), synthetic corticosteroid; metabolically interconvertible with prednisone. Epiprednisolone (Prednisolone EP Impurity F) is a derivative of prednisolone (P703740), synthetic corticosteroid; metabolically interconvertible with prednisone.

Technology Process of Epiprednisolone

There total 14 articles about Epiprednisolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.2%

: C₂₁H₂₇BrO₅

: 50-24-8,600-90-8,30915-16-3,8056-11-9
Prednisolone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; cyclohexene; 1,1'-azobis(1-cyanocyclohexanenitrile); In isopropyl alcohol; at 75 ℃; Green chemistry;