4-(4-Biphenylyl)-2-methylthiazole

Base Information

• Chemical Name: 4-(4-Biphenylyl)-2-methylthiazole
• CAS No.: 24864-19-5
• Molecular Formula: C16H13NS
• Molecular Weight: 251.352
• Hs Code.: 29341000
• European Community (EC) Number: 246-505-1
• NSC Number: 122283
• UNII: SXR7D2V9JP
• DSSTox Substance ID: DTXSID70179575
• Nikkaji Number: J124.151F
• Wikidata: Q83050109
• Mol file: 24864-19-5.mol

Synonyms:24864-19-5;4-(4-Biphenylyl)-2-methylthiazole;4-([1,1'-biphenyl]-4-yl)-2-methylthiazole;2-methyl-4-(4-phenylphenyl)-1,3-thiazole;2-Methyl-4-(4-biphenylyl)thiazole;Thiazole, 4-(4-biphenylyl)-2-methyl-;4-(4-Biphenylyl)-2-methyl-1,3-thiazole;SXR7D2V9JP;Thiazole, 4-(1,1'-biphenyl)-4-yl-2-methyl-;EINECS 246-505-1;NSC-122283;Thiazole, 4-[1,1'-biphenyl]-4-yl-2-methyl-;4-(biphenyl-4-yl)-2-methylthiazole;NSC122283;UNII-SXR7D2V9JP;SCHEMBL9528793;DTXSID70179575;MFCD00005333;STL456034;AKOS001619905;4-(Biphenyl-4-yl)-2-methyl-thiazole;CCG-107687;NSC 122283;Thiazole, 4-(4-biphenyl)-2-methyl-;Thiazole,1'-biphenyl]-4-yl-2-methyl-;4-(biphenyl-4-yl)-2-methyl-1,3-thiazole;CS-0336226;FT-0638461;2-Methyl-4-(4-biphenyl)thiazole, AldrichCPR;4-(1,1'-biphenyl-4-yl)-2-methyl-1,3-thiazole;A817525;SR-01000449365;4-(1,1'-BIPHENYL)-4-YL-2-METHYLTHIAZOLE;SR-01000449365-1;4-[1,1'-Biphenyl]-4-yl-2-methyl-1,3-thiazole #;4-{[1,1'-BIPHENYL]-4-YL}-2-METHYL-1,3-THIAZOLE

Chemical Property of 4-(4-Biphenylyl)-2-methylthiazole

Chemical Property:

• Appearance/Colour: Beige-brown crystalline powder
• Vapor Pressure: 3.05E-07mmHg at 25°C
• Melting Point: 113-118 °C
• Refractive Index: 1.618
• Boiling Point: 431.3°Cat760mmHg
• Flash Point: 218.3°C
• PSA: 41.13000
• Density: 1.147g/cm³
• LogP: 4.78550
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 251.07687059
• Heavy Atom Count: 18
• Complexity: 254

Purity/Quality:

98%min ^*data from raw suppliers

4-(4-BIPHENYLYL)-2-METHYLTHIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 24/25-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=CS1)C2=CC=C(C=C2)C3=CC=CC=C3

Technology Process of 4-(4-Biphenylyl)-2-methylthiazole

There total 5 articles about 4-(4-Biphenylyl)-2-methylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-(4-bromophenyl)-2-methyl-1,3-thiazole (66047-74-3) + phenylboronic acid (98-80-6) → 4-([1,1'-biphenyl]-4-yl)-2-methylthiazole (24864-19-5)

Guidance literature:

With dichloro[N-hydroxy-1-(1-methyl-1H-benzimidazol-2-yl-κN3)ethanamine-κN]palladium; tetrabutylammomium bromide; potassium hydroxide; In water; at 160 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1055/s-0029-1218662

Reference yield: 80.0%

4-(4-chlorophenyl)-2-methyl-1,3-thiazole (24840-75-3) + phenylboronic acid (98-80-6) → 4-([1,1'-biphenyl]-4-yl)-2-methylthiazole (24864-19-5)

Guidance literature:

With dichloro[N-hydroxy-1-(1-methyl-1H-benzimidazol-2-yl-κN3)ethanamine-κN]palladium; tetrabutylammomium bromide; potassium hydroxide; In water; at 160 ℃; for 0.5h; Microwave irradiation;

DOI:10.1055/s-0029-1218662

Reference yield: 54.0%

4-acetylbiphenyl oxime (75408-89-8) + acetic anhydride (108-24-7) → 4-([1,1'-biphenyl]-4-yl)-2-methylthiazole (24864-19-5)

Guidance literature:

With copper(l) iodide; potassium thioacyanate; In toluene; at 120 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.joc.6b02124

upstream raw materials:

4-(chloroacetyl)biphenyl

thioacetamide

4-(4-chlorophenyl)-2-methyl-1,3-thiazole

phenylboronic acid

Refernces

• 1、 Dawood, Kamal M.,El-Deftar, Moteaa M.. "Microwave-assisted synthesis of 2-substituted 4-biarylyl-1,3-thiazoles by carbon-carbon cross-coupling in water". experimental part. p. 1030 - 1038. Retrieved 2010/06/16.