4-BroMo-2-Methyl-6-iodoaniline

Base Information

• Chemical Name: 4-BroMo-2-Methyl-6-iodoaniline
• CAS No.: 922170-67-0
• Molecular Formula: C7H7BrIN
• Molecular Weight: 311.948
• Mol file: 922170-67-0.mol

Synonyms:4-Bromo-2-iodo-6-methylbenzenamine;Benzenamine,4-bromo-2-iodo-6-methyl;

Chemical Property of 4-BroMo-2-Methyl-6-iodoaniline

Chemical Property:

• Boiling Point: 302.8±42.0 °C(Predicted)
• PKA: 1.69±0.10(Predicted)
• PSA: 26.02000
• Density: 2.133±0.06 g/cm3(Predicted)
• LogP: 3.52550
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

4-Bromo-2-iodo-6-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BroMo-2-Methyl-6-iodoaniline

There total 1 articles about 4-BroMo-2-Methyl-6-iodoaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.4%

4-Bromo-2-methylaniline (583-75-5) → 4-bromo-2-iodo-6-methylaniline (922170-67-0)

Guidance literature:

With N-iodo-succinimide; acetic acid; at 20 - 30 ℃; for 2h;

Reference yield: 92.3%

4-bromo-2-iodo-6-methylaniline (922170-67-0) + trimethylsilylacetylene (1066-54-2) → 4-bromo-6-(trimethylsilylacetylenyl)-2-methylaniline

Guidance literature:

With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine; In tetrahydrofuran; at 20 ℃; for 2h; Reagent/catalyst; Inert atmosphere;

Reference yield: 91.0%

4-bromo-2-iodo-6-methylaniline (922170-67-0) → 5-bromo-2-fluoro-1-iodo-3-methylbenzene

Guidance literature:

With pyridine hydrogenfluoride; sodium nitrite; at 0 - 90 ℃;

upstream raw materials:

4-Bromo-2-methylaniline

Downstream raw materials:

N-(4-bromo-2-iodo-6-methylphenyl)-N,2-dimethyl-(2E)-butenamide

tert-butyl 4-bromo-2-iodo-6-methylphenylcarbamate

1-bromo-3-iodo-5-methylbenzene

5-bromo-7-iodo-1H-indazole

Refernces

• 1、 Yang, Bowen,Wu, Qian,Huan, Xiajuan,Wang, Yingqing,Sun, Yin,Yang, Yueyue,Liu, Tongchao,Wang, Xin,Chen, Lin,Xiong, Bing,Zhao, Dongmei,Miao, Zehong,Chen, Danqi. "Discovery of a series of 1H-pyrrolo[2,3-b]pyridine compounds as potent TNIK inhibitors". supporting information. . Retrieved 2020/12/28.
• 2、 Ong, Jun-Yang,Ng, Xiao Qian,Lu, Shenci,Zhao, Yu. "Isothiourea-Catalyzed Atroposelective N-Acylation of Sulfonamides". supporting information. p. 6447 - 6451. Retrieved 2020/09/02.