3,4-Dichloro-5-methoxy-2(5H)-furanone

Base Information

• Chemical Name: 3,4-Dichloro-5-methoxy-2(5H)-furanone
• CAS No.: 23066-93-5
• Molecular Formula: C5H4 Cl2 O3
• Molecular Weight: 182.991
• DSSTox Substance ID: DTXSID80945743
• Nikkaji Number: J534.616I
• ChEMBL ID: CHEMBL4238251
• Mol file: 23066-93-5.mol

Synonyms:3,4-Dichloro-5-methoxy-2(5H)-furanone;BRN 0127365;2(5H)-FURANONE, 3,4-DICHLORO-5-METHOXY-;3,4-dichloro-5-methoxyfuran-2(5h)-one;23066-93-5;CHEMBL4238251;SCHEMBL14505730;QSPUPLRXWNBTDL-UHFFFAOYSA-;DTXSID80945743;LS-70366;5-18-01-00049 (Beilstein Handbook Reference)

Chemical Property of 3,4-Dichloro-5-methoxy-2(5H)-furanone

Chemical Property:

• Vapor Pressure: 0.00663mmHg at 25°C
• Boiling Point: 271°C at 760 mmHg
• Flash Point: 128.3°C
• Density: 1.53g/cm³
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 181.9537494
• Heavy Atom Count: 10
• Complexity: 199

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1C(=C(C(=O)O1)Cl)Cl

Technology Process of 3,4-Dichloro-5-methoxy-2(5H)-furanone

There total 6 articles about 3,4-Dichloro-5-methoxy-2(5H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methanol (67-56-1) + Mucochloric acid (766-40-5) → 3,4-dichloro-5-methoxy-2-(5H)furanone (23066-93-5)

Guidance literature:

With sulfuric acid; In 1,2-dichloro-ethane; Reflux;

DOI:10.1039/d1ra00750e

Reference yield: 90.0%

methanol (67-56-1) + C5H4Cl2O2 → 3,4-dichloro-5-methoxy-2-(5H)furanone (23066-93-5)

Guidance literature:

With sulfuric acid; In 1,2-dichloro-ethane; for 36.3333h; Reflux;

DOI:10.1016/j.ejmech.2021.113295

Reference yield: 60.0%

methanol (67-56-1) + mucochloric acid (87-56-9) → 3,4-dichloro-5-methoxy-2-(5H)furanone (23066-93-5)

Guidance literature:

methanol; mucochloric acid; With sulfuric acid; at 70 ℃;

With potassium carbonate; for 0.5h;

upstream raw materials:

methanol

mucochloric acid

Mucochloric acid

α,β-dichloro-γ-phenyl-Δ^α,β-crotonolactone

Downstream raw materials:

3,4-Dichloro-5-methoxy-1-(4-methoxy-benzyl)-1,5-dihydro-pyrrol-2-one

Refernces

• 1、 Wei, Meng-Xue,Yu, Jia-Ying,Liu, Xin-Xin,Li, Xue-Qiang,Zhang, Meng-Wei,Yang, Pei-Wen,Yang, Jin-Hui. "Synthesis of artemisinin-piperazine-furan ether hybrids and evaluation of in vitro cytotoxic activity". . . Retrieved 2021.
• 2、 -. "Preparation and use of halobutenolide-like compound having insecticidal activity". Paragraph 0032; 0033; 0034. . Retrieved 2019/02/25.