MONOMETHYL 3-METHYLGLUTARATE

Base Information

• Chemical Name: MONOMETHYL 3-METHYLGLUTARATE
• CAS No.: 27151-65-1
• Molecular Formula: C7H12O4
• Molecular Weight: 160.17
• Hs Code.: 2918990090
• Mol file: 27151-65-1.mol

Synonyms:Glutaricacid, 3-methyl-, methyl ester (6CI);Glutaric acid, 3-methyl-, monomethyl ester(8CI);Pentanedioic acid, 3-methyl-, monomethyl ester (9CI);NSC 249823;Monomethyl β-methylglutarate;

Chemical Property of MONOMETHYL 3-METHYLGLUTARATE

Chemical Property:

• Vapor Pressure: 0.000479mmHg at 25°C
• Refractive Index: 1.442
• Boiling Point: 291.6 °C at 760 mmHg
• PKA: 4?+-.0.10(Predicted)
• Flash Point: 108.4 °C
• PSA: 63.60000
• Density: 1.123 g/cm³
• LogP: 0.66030
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

5-methoxy-3-methyl-5-oxopentanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of MONOMETHYL 3-METHYLGLUTARATE

There total 9 articles about MONOMETHYL 3-METHYLGLUTARATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 3-methylglutaric anhydride (4166-53-4) → 3-methyl-1,5-pentanedioic acid monomethyl ester (27151-65-1)

Guidance literature:

at 80 ℃; for 0.75h;

DOI:10.1002/1099-0690(20021)2002:1<189::AID-EJOC189>3.0.CO;2-8

Reference yield: 97.0%

dimethyl 3-methylglutarate (19013-37-7) → 3-methyl-1,5-pentanedioic acid monomethyl ester (27151-65-1)

Guidance literature:

With pig liver esterase; water; sodium hydroxide; In methanol; aq. phosphate buffer; at -10 ℃; for 10h; pH=6 - 7.5; Inert atmosphere; Enzymatic reaction;

DOI:10.1039/c7ob03204h

Reference yield: 97.0%

(S)-5-methoxy-3-methyl-5-oxopentanoic acid (63473-60-9) + sodium methylate (124-41-4) → 3-methyl-1,5-pentanedioic acid monomethyl ester (27151-65-1)

Guidance literature:

With potassium hydroxide; acetic anhydride; Product distribution; Multistep reaction;

DOI:10.1016/S0040-4020(01)96510-X

upstream raw materials:

methanol

3-methyl glutaric acid

3-methylglutaric anhydride

sodium methylate

Downstream raw materials:

3-methyldodecanoic acid

(R)-3-methylpentanedioic acid monomethyl ester

3-methylundecanoic acid

4-methyl-tetrahydro-pyran-2-one

Refernces

• 1、 Craig, Ryan,Litvajova, Mili,Cronin, Sarah A.,Connon, Stephen J.. "Enantioselective acyl-transfer catalysis by fluoride ions". supporting information. p. 10108 - 10111. Retrieved 2018/09/18.
• 2、 -. "Preparation method of high-purity and high-yield monomethyl 3-methylglutarate". Paragraph 0033; 0034; 0046-0048; 0053; 0057-0063; 0068-0074. . Retrieved 2018/09/08.