4-fluoro-2,6-dinitroaniline

Base Information

• Chemical Name: 4-fluoro-2,6-dinitroaniline
• CAS No.: 82366-44-7
• Molecular Formula: C6H4FN3O4
• Molecular Weight: 201.1121
• Mol file: 82366-44-7.mol

Synonyms:

Chemical Property of 4-fluoro-2,6-dinitroaniline

Chemical Property:

• Vapor Pressure: 1.7E-05mmHg at 25°C
• Boiling Point: 364.3°Cat760mmHg
• Flash Point: 174.1°C
• Density: 1.681g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-fluoro-2,6-dinitroaniline

There total 6 articles about 4-fluoro-2,6-dinitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,6-dinitro-4-fluoroanisole (342-49-4) → 4-Fluoro-2,6-dinitroaniline (82366-44-7)

Guidance literature:

With ammonia; In methanol; for 15h; Reflux;

DOI:10.1002/ejoc.201600657

Reference yield: 52.0%

4-fluoro-2,6-dinitro-(trifluoroacetamido)benzene → 4-Fluoro-2,6-dinitroaniline (82366-44-7)

Guidance literature:

In potassium carbonate;

Reference yield:

4-Fluorophenol (371-41-5) → 4-Fluoro-2,6-dinitroaniline (82366-44-7)

Guidance literature:

Multi-step reaction with 4 steps

1: nitric acid / dichloromethane / 18 h / 0 - 20 °C

2: potassium carbonate / ethanol; water / 0.17 h / 20 °C

3: acetonitrile

4: ammonia / methanol / 15 h / Reflux

With ammonia; nitric acid; potassium carbonate; In methanol; ethanol; dichloromethane; water; acetonitrile;

DOI:10.1002/ejoc.201600657

upstream raw materials:

2,6-dinitro-4-fluoroanisole

4-Fluorophenol

1-fluoro-4-methoxybenzene

4-fluoro-2,6-dinitrophenol

Downstream raw materials:

1,2-diamino-4-fluoro-6-nitrobenzene

Refernces

• 1、 -. "Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones". . . Retrieved 2008/06/13.
• 2、 Kuznetsov, L. L.,Gidaspov, B. V.. "EFFECT OF STRUCTURE ON THE BASICITY OF AROMATIC AMINES". . p. 595 - 601. Retrieved 2007/10/02.