2,3,5-trimethyl-1H-indene

Base Information

• Chemical Name: 2,3,5-trimethyl-1H-indene
• CAS No.: 66703-26-2
• Molecular Formula: C12H14
• Molecular Weight: 158.2396
• Mol file: 66703-26-2.mol

Synonyms:

Chemical Property of 2,3,5-trimethyl-1H-indene

Chemical Property:

• Vapor Pressure: 0.0651mmHg at 25°C
• Boiling Point: 238.5°Cat760mmHg
• Flash Point: 92.4°C
• Density: 0.964g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,5-trimethyl-1H-indene

There total 6 articles about 2,3,5-trimethyl-1H-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H16O → 2,3,5-trimethyl-1H-indene (66703-26-2)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; at 90 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.9b02512

Reference yield:

2,6-dimethylindan-1-one (66309-83-9) → 2,3,5-trimethyl-1H-indene (66703-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 20 °C / Inert atmosphere

2: toluene-4-sulfonic acid / benzene / 90 °C / Inert atmosphere

With toluene-4-sulfonic acid; In tetrahydrofuran; benzene;

DOI:10.1021/acs.orglett.9b02512

Reference yield:

2,3-dihydro-6-methyl-1H-inden-1-one (24623-20-9) → 2,3,5-trimethyl-1H-indene (66703-26-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 20 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid / benzene / 90 °C / Inert atmosphere

With toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; benzene;

DOI:10.1021/acs.orglett.9b02512

upstream raw materials:

3-methyl-4-(p-tolyl)butan-2-one

1,1-dichloro-2,2-dimethylcyclopropane

toluene

2,6-dimethylindan-1-one

Refernces