17beta-hydroxy-4,17-dimethylandrost-4-en-3-one

Base Information

• Chemical Name: 17beta-hydroxy-4,17-dimethylandrost-4-en-3-one
• CAS No.: 28626-76-8
• Molecular Formula: C21H32 O2
• Molecular Weight: 316.484
• Mol file: 28626-76-8.mol

Synonyms:Androst-4-en-3-one,17b-hydroxy-4,17-dimethyl-(7CI,8CI); Testosterone, 4,17-dimethyl- (6CI); 17b-Hydroxy-4,17-dimethyl-4-androsten-3-one; 4,17a-Dimethyltestosterone

Chemical Property of 17beta-hydroxy-4,17-dimethylandrost-4-en-3-one

Chemical Property:

• Melting Point: 141-142 °C
• Boiling Point: 439.1°Cat760mmHg
• PKA: 15.13±0.70(Predicted)
• Flash Point: 187.2°C
• PSA: 37.30000
• Density: 1.09g/cm³
• LogP: 4.65940

Purity/Quality:

98%Min ^*data from raw suppliers

4,17a-Dimethyltestosterone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Testosterone (T155000) derivative. Intermediate in the preparation of Epostane (E588850).

Technology Process of 17beta-hydroxy-4,17-dimethylandrost-4-en-3-one

There total 3 articles about 17beta-hydroxy-4,17-dimethylandrost-4-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

17-methyltestosterone (58-18-4) + methyl iodide (74-88-4) → 17β-hydroxy-4,17-dimethyl-4-androsten-3-one (28626-76-8)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; Heating;

DOI:10.1021/ja01496a044

Reference yield:

→ 17β-hydroxy-4,17-dimethyl-4-androsten-3-one (28626-76-8)

Guidance literature:

17α-Methyl-4-phenylmercaptomethyl-testosteron, Raney-Nickel, Aceton, Erwaermen; Hydrogenolyse;

Reference yield:

→ 17β-Hydroxy-4,17α-dimethylandrost-4-en-3-on (6725-98-0,28626-76-8)

Guidance literature:

entspr. 4-Phenylthiomethylverb., Raney-Ni;

upstream raw materials:

17-methyltestosterone

methyl iodide

Downstream raw materials:

(Z)-17β-hydroxy-2-hydroxymethylene-4,17α-dimethylandrost-4-en-3-one

4,17-dimethyl-androst-4-eno[2,3-d]isoxazol-17β-ol

C₂₂H₃₁NO₃

4α,5α-epoxy-17β-hydroxy-4β,17α-dimethyl-3-oxoandrostene-2α-carbonitrile