Benzene, 2-fluoro-4-iodo-1-Methoxy-

Base Information

• Chemical Name: Benzene, 2-fluoro-4-iodo-1-Methoxy-
• CAS No.: 3824-21-3
• Molecular Formula: C7H6FIO
• Molecular Weight: 252.027
• Hs Code.: 2909309090
• Mol file: 3824-21-3.mol

Synonyms:(3-fluoro-4-methoxyphenyl) iodide;2-Fluor-4-jod-anisol;2-fluoro-4-iodo-anisole;2-fluoro-4-iodo-1-methoxy-benzene;

Chemical Property of Benzene, 2-fluoro-4-iodo-1-Methoxy-

Chemical Property:

• Vapor Pressure: 0.0694mmHg at 25°C
• Melting Point: 34 °C
• Boiling Point: 237.3°Cat760mmHg
• Flash Point: 97.3°C
• PSA: 9.23000
• Density: 1.803g/cm³
• LogP: 2.43890
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-4-iodo-1-methoxybenzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, 2-fluoro-4-iodo-1-Methoxy-

There total 1 articles about Benzene, 2-fluoro-4-iodo-1-Methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-fluoro-4-methoxyaniline (366-99-4) → (3-fluoro-4-methoxyphenyl) iodide (3824-21-3)

Guidance literature:

3-fluoro-4-methoxyaniline; With hydrogenchloride; In water; for 0.0833333h; Heating;

With sodium iodide; sodium nitrite; In water; at -5 - 20 ℃; for 10h;

DOI:10.1055/s-0031-1290899

Reference yield: 87.0%

L-valine ethyl ester (17431-03-7) + (3-fluoro-4-methoxyphenyl) iodide (3824-21-3) → (S)-ethyl 2-(5-iodo-2-methoxyphenylamino)-3-methylbutanoate

Guidance literature:

With 3,6‐di‐tert‐butyl‐9‐mesityl‐10‐phenylacridin‐10‐ium tetrafluoroborate; In 1,2-dichloro-ethane; at 25 ℃; for 48h; Irradiation; Inert atmosphere;

Reference yield: 73.0%

4-methylsulfanyl-2-butanone (34047-39-7) + carbon monoxide (201230-82-2) + (3-fluoro-4-methoxyphenyl) iodide (3824-21-3) → C9H9FOS2

Guidance literature:

With potassium tert-butylate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium dichloride; In 5,5-dimethyl-1,3-cyclohexadiene; at 130 ℃; for 16h; under 15001.5 Torr;

DOI:10.1039/c9sc05532k

upstream raw materials:

3-fluoro-4-methoxyaniline

Downstream raw materials:

2-fluoro-4-iodophenol

2-fluoro-6-iodo-3-methoxybenzonitrile

4-(4-aminophenyl)-7-methoxy-1H-indazol-3-amine

2-fluoro-3-hydroxy-6-iodobenzonitrile

Refernces