2-Amino-4'-methylbenzophenone

Base Information

• Chemical Name: 2-Amino-4'-methylbenzophenone
• CAS No.: 36192-63-9
• Molecular Formula: C14H13 N O
• Molecular Weight: 211.263
• Hs Code.: 29223900
• European Community (EC) Number: 252-905-7
• DSSTox Substance ID: DTXSID50189758
• Nikkaji Number: J89.092H
• Wikidata: Q83061964
• Mol file: 36192-63-9.mol

Synonyms:2-Amino-4'-methylbenzophenone;36192-63-9;(2-AMINOPHENYL)(P-TOLYL)METHANONE;(2-aminophenyl)-(4-methylphenyl)methanone;2-Amino-4'-methylbenzophenone m;EINECS 252-905-7;Methanone, (2-aminophenyl)(4-methylphenyl)-;2-(4-methylbenzoyl)aniline;SCHEMBL4639277;DTXSID50189758;MFCD00007716;AKOS005135765;SB77367;AS-38736;(2-Aminophenyl)(4-methylphenyl)methanone #;FT-0611124;EN300-156817;A823160;SR-01000317399;SR-01000317399-1;F1968-0048;Z203886646

Chemical Property of 2-Amino-4'-methylbenzophenone

Chemical Property:

• Melting Point: 91 °C
• Refractive Index: 1.5780 (estimate)
• Boiling Point: 407.1°Cat760mmHg
• Flash Point: 200°C
• PSA: 43.09000
• Density: 1.135g/cm³
• LogP: 3.38940
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 211.099714038
• Heavy Atom Count: 16
• Complexity: 243

Purity/Quality:

98%min ^*data from raw suppliers

(2-Aminophenyl)(P-tolyl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(=O)C2=CC=CC=C2N
• Uses: 2-Amino-4-methyl-benzophenone is used in the palladium-catalyzed preparation and antitumor activity of 2-aminobenzophenones, benzoyloxoindolines, and 7-benzoylindoles.

Technology Process of 2-Amino-4'-methylbenzophenone

There total 49 articles about 2-Amino-4'-methylbenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-methylphenylboronic acid (5720-05-8) + anthranilic acid nitrile (1885-29-6) → 2-amino-4'-methylbenzophenone (36192-63-9)

Guidance literature:

With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate; water; In 2-methyltetrahydrofuran; at 80 ℃; for 36h; Schlenk technique;

DOI:10.1039/c4ob00978a

Reference yield: 88.0%

sodium 4-methylbenzenesulfinate (824-79-3) + anthranilic acid nitrile (1885-29-6) → 2-amino-4'-methylbenzophenone (36192-63-9)

Guidance literature:

With p-nitrobenzenesulfonic acid; palladium diacetate; In tetrahydrofuran; water; at 80 ℃; for 48h; Inert atmosphere; Schlenk technique;

DOI:10.3390/molecules19056439

Reference yield: 79.0%

2-(toluene-4-sulfonylamino)-benzoic acid (6311-23-5) → 2-amino-4'-methylbenzophenone (36192-63-9)

Guidance literature:

With dipotassium hydrogenphosphate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; triphenylphosphine; In 1,4-dioxane; at 25 ℃; for 8h; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1002/chem.201903816

upstream raw materials:

2-N-(p-methylbenzenesulfonyl)amino-4'-methyl-benzophenone

2-(toluene-4-sulfonylamino)-benzoic acid

(4-methylphenyl)(2-nitrophenyl)methanone

2-p-toluoyl-benzoic acid amide

Downstream raw materials:

N-(2-p-toluoyl-phenyl)-phthalimide

(2-aminophenyl)(p-tolyl)methanol

2-amino-4'-methyldiphenylmethane

12-p-tolyl-isochromeno[3,4-b]quinolin-5-one

Refernces

• 1、 Fan, Hui,Xu, Shijie,Yang, Fan,Zhang, Xiaoxiang,Zhao, Xuechun. "One-Pot Synthesis of 2-Aminobenzophenones from 2-Alkynyl Arylazides Catalyzed by Pd and Cu Precursors". supporting information. p. 4555 - 4558. Retrieved 2021/08/30.
• 2、 -. "Method for synthesizing ortho-amino aromatic ketone from aromatic carboxylic acid". Paragraph 0025; 0026. . Retrieved 2019/07/04.