Spermine hydrochloride

Base Information

• Chemical Name: Spermine hydrochloride
• CAS No.: 306-67-2
• Molecular Formula: C10H26 N4 . 4 Cl H
• Molecular Weight: 348.187
• Hs Code.: 29212900
• NSC Number: 69852
• DSSTox Substance ID: DTXSID40952079
• ChEMBL ID: CHEMBL1256357
• Mol file: 306-67-2.mol

Synonyms:Spermine tetra, HCl;Spermine hydrochloride;NSC69852;spermidine 3HCl;N,N'-bis(3-aminopropyl)butane-1,4-diamine;hydrochloride;MLS002472980;3-azaniumylpropyl-[4-(3-azaniumylpropylazaniumyl)butyl]azanium;tetrachloride;SPERMINE, TETRAHYDROCHLORIDE;NSC-69852;SMR001397086;Spermine hydrochlorine;SCHEMBL1167355;CHEMBL1256357;DTXSID40952079;Spermine tetrahydrochloride, 98%;KBDDIZRDKLGWGW-UHFFFAOYSA-N;N,4-butanediamine tetrahydrochloride;1, N,N'-bis(3-aminopropyl), tetrahydrochloride;1, N,N'-bis(3-aminopropyl)-, tetrahydrochloride;3-[4-(3-aminopropylamino)butylamino]propylazanium chloride;N~1~,N~4~-Bis(3-aminopropyl)butane-1,4-diamine--hydrogen chloride (1/1)

Chemical Property of Spermine hydrochloride

Chemical Property:

• Vapor Pressure: 0.000683mmHg at 25°C
• Melting Point: 310-311 °C (dec.)(lit.)
• Boiling Point: 308.4°Cat760mmHg
• Flash Point: 175.6°C
• PSA: 76.10000
• Density: 0.925g/cm³
• LogP: 5.03380
• Storage Temp.: 2-8°C
• Solubility.: H2O: 1 M at 20 °C, clear, colorless
• Water Solubility.: Soluble in water (348.2 g/L at 20°C).
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 11
• Exact Mass: 238.1924246
• Heavy Atom Count: 15
• Complexity: 86.1

Purity/Quality:

99%, ^*data from raw suppliers

Spermine, Tetrahydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Uses -> Biochemical Research
• Canonical SMILES: C(CCNCCCN)CNCCCN.Cl
• Uses: Spermine Tetrahydrochloride is an inhibitor of NOS1, NMDA, GluR, and PLCα. A useful reactant for Surface-?enhanced Raman spectroscopy (SERS) characterization of abasic sites in DNA duplexes. Spermine tetrahydrochloride was used to precipitate DNA for flow cytometric analysis from fresh frozen breast cancer tissue, archival tissue of salivary gland, renal and thyroid tumors and red blood cells of chicken. Used to precipitate DNA from low salt aqueous buffers.

Technology Process of Spermine hydrochloride

There total 3 articles about Spermine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[4-(2-methoxycarbonyl-acetylamino)-butyl]-malonamic acid methyl ester (477808-23-4) → spermine tetrahydrochloride (306-67-2)

Guidance literature:

Multi-step reaction with 3 steps

1: NH₃ / methanol / 7 °C

2: BH₃*THF / tetrahydrofuran / 7 h / Heating

3: conc. HCl

With hydrogenchloride; borane-THF; ammonia; In tetrahydrofuran; methanol;

DOI:10.1081/SCC-120003392

Reference yield:

3,10-dioxo-4,9-diazadodecanediamide (477808-25-6) → spermine tetrahydrochloride (306-67-2)

Guidance literature:

Multi-step reaction with 2 steps

1: BH₃*THF / tetrahydrofuran / 7 h / Heating

2: conc. HCl

With hydrogenchloride; borane-THF; In tetrahydrofuran;

DOI:10.1081/SCC-120003392

Reference yield:

Spermine (71-44-3) → spermine tetrahydrochloride (306-67-2)

Guidance literature:

With hydrogenchloride;

DOI:10.1081/SCC-120003392

upstream raw materials:

Spermine

N-[4-(2-methoxycarbonyl-acetylamino)-butyl]-malonamic acid methyl ester

3,10-dioxo-4,9-diazadodecanediamide

Downstream raw materials:

C₅₆H₇₃F₁₂N₆O₉P

N₁-[4-(dimethoxytrityloxy)butyl]-N₁₂-(4-hydroxybutyl)-N₁,N₄,N₉,N₁₂-tetrakis(trifluoroacetyl)spermine

C₃₈H₅₀N₁₂

N¹,N⁴,N⁹,N¹²-tetrakis(mesityenesulfonyl)spermine

Refernces