Ferric maltol

Base Information

• Chemical Name: Ferric maltol
• CAS No.: 33725-54-1
• Molecular Formula: C₁₈H₁₅FeO₉
• Molecular Weight: 431.159
• UNII: MA10QYF1Z0
• Wikipedia: Ferric_maltol
• Wikidata: Q27283748
• NCI Thesaurus Code: C174702
• RXCUI: 2539932
• Mol file: 33725-54-1.mol

Synonyms:Accrufer;ferric maltol;iron (III) maltol;iron(3+) tris(2-methyl-4-oxo-4H-pyran-3-olate)

Chemical Property of Ferric maltol

Chemical Property:

• Vapor Pressure: 0.000337mmHg at 25°C
• Boiling Point: 284.7°C at 760 mmHg
• Flash Point: 127.3°C
• PSA: 159.81000
• LogP: 3.27350
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 0
• Exact Mass: 431.006543
• Heavy Atom Count: 28
• Complexity: 200

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(C(=O)C=CO1)[O-].CC1=C(C(=O)C=CO1)[O-].CC1=C(C(=O)C=CO1)[O-].[Fe+3]
• Recent ClinicalTrials: Predicting Response to Iron Supplementation in Patients With Active Inflammatory Bowel Disease
• Recent EU Clinical Trials: A pilot study to explore safety, tolerability and efficacy of ORal IrON supplementation with ferric maltol in treating iron deficiency and anaemia in patients with Heart Failure (ORION-HF)
• Description: Ferric maltol is an orally active complex of a single iron ion (Fe3+).
• Uses: Ferric maltol can be used in the study of iron deficiency anemia in inflammatory bowel disease.

Technology Process of Ferric maltol

There total 4 articles about Ferric maltol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Maltol (118-71-8) + iron(III) chloride hexahydrate → mer-tris(3-hydroxy-2-methyl-4H-pyran-4-onato)iron(III) (115648-45-8,181656-66-6,33725-54-1)

Guidance literature:

iron(III) chloride hexahydrate; With sodium hydroxide; In water;

Maltol; With L-lysine; In water; Reagent/catalyst;

Reference yield:

Maltol (118-71-8) + iron (7439-89-6) → mer-tris(3-hydroxy-2-methyl-4H-pyran-4-onato)iron(III) (115648-45-8,181656-66-6,33725-54-1)

Guidance literature:

Maltol; With sodium hydroxide; In water;

iron; With oxygen; In water; for 120h;

Reference yield:

Maltol (118-71-8) + iron(III) chloride hexahydrate (121714-78-1,24290-40-2,58694-80-7,10025-77-1,64333-00-2) → mer-tris(3-hydroxy-2-methyl-4H-pyran-4-onato)iron(III) (115648-45-8,181656-66-6,33725-54-1)

Guidance literature:

In water; aq. solns. of Fe salt and ligand (molar ratio 1:5) mixed at pH 5-6; not isolated; detd. by method of isomolar series;

DOI:10.1023/B:RUCB.0000037841.67079.2b

upstream raw materials:

Maltol

iron(III) chloride hexahydrate

iron(III) chloride

iron

Refernces

• 1、 -. "METHODS FOR PRODUCING FERRIC MALTOL COMPOSITIONS FROM LIGAND MODIFIED AND LIGAND COATED FERRIC HYDROXIDES". Page/Page column 18; 19. . Retrieved 2017/10/31.
• 2、 Antipova,Mukha,Medvedeva. "Determination of composition and instability constants of maltol complexes with iron(III) ions". . p. 780 - 784. Retrieved 2007/10/03.