5-(4-Chloro-2-nitrophenyl)-2H-tetrazole

Base Information

• Chemical Name: 5-(4-Chloro-2-nitrophenyl)-2H-tetrazole
• CAS No.: 92567-02-7
• Molecular Formula: C₇H₄ClN₅O₂
• Molecular Weight: 225.594
• Mol file: 92567-02-7.mol

Synonyms:

Chemical Property of 5-(4-Chloro-2-nitrophenyl)-2H-tetrazole

Chemical Property:

• Boiling Point: 439.1±55.0 °C(Predicted)
• PKA: 3.23±0.10(Predicted)
• PSA: 33.12000
• Density: 1.652±0.06 g/cm3(Predicted)
• LogP: 3.25970

Purity/Quality:

98%min ^*data from raw suppliers

5-(4-Chloro-2-nitrophenyl)-2H-tetrazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(4-Chloro-2-nitrophenyl)-2H-tetrazole

There total 1 articles about 5-(4-Chloro-2-nitrophenyl)-2H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-2-nitrobenzonitrile (34662-32-3) → C7H4ClN5O2 (92567-02-7)

Guidance literature:

With sodium azide; triethylamine hydrochloride; In toluene; at 65 - 70 ℃; for 3h;

Reference yield:

C7H4ClN5O2 (92567-02-7) → 5-(2-amino-4-chloro-5-sulphamoylphenyl)tetrazole (82212-14-4)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / 7500.75 Torr / Autoclave

2: chlorosulfonic acid / 2 h / 60 - 95 °C

3: ammonia / ethyl acetate / 1 h / 15 - 35 °C

With chlorosulfonic acid; palladium 10% on activated carbon; ammonia; hydrogen; In ethyl acetate;

Reference yield:

C7H4ClN5O2 (92567-02-7) → C7H5Cl2N5O2S

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / 7500.75 Torr / Autoclave

2: chlorosulfonic acid / 2 h / 60 - 95 °C

With chlorosulfonic acid; palladium 10% on activated carbon; hydrogen;

upstream raw materials:

4-chloro-2-nitrobenzonitrile

Downstream raw materials:

5-(2-amino-4-chloro-5-sulphamoylphenyl)tetrazole

Refernces