3-(Bromomethyl)pyridine hydrobromide

Base Information

• Chemical Name: 3-(Bromomethyl)pyridine hydrobromide
• CAS No.: 4916-55-6
• Molecular Formula: BrH*C₆H₆BrN
• Molecular Weight: 252.936
• Hs Code.: 2933399090
• European Community (EC) Number: 628-885-4
• DSSTox Substance ID: DTXSID10507530
• NSC Number: 338478
• Mol file: 4916-55-6.mol

Synonyms:3-(Bromomethyl)pyridine hydrobromide;4916-55-6;3-Picolyl Bromide Hydrobromide;3-bromomethyl-pyridine hydrobromide;3-(BROMOMETHYL)PYRIDINE HBR;3-(bromomethyl)pyridine;hydrobromide;MFCD01321314;3-Bromomethylpyridine (hydrobromide);Pyridine, 3-(bromomethyl)-, hydrobromide;3-(Bromomethyl)pyridineHydrobromide;3-(brommethyl)pyridine-hbr;SCHEMBL146199;DTXSID10507530;3-Bromomethylpyridine hydrobromide;FNHPUOJKUXFUKN-UHFFFAOYSA-N;3-bromomethyl pyridine hydrobromide;STR07573;3-bromomethylpyridine hydrogenbromide;NSC338478;3-(bromomethyl)-pyridine hydrobromide;3-(bromomethyl)pyridin-1-ium bromide;3-(BROMOMETHYL)PYRIDINE, HBR;3-(bromomethyl)pyridine, hydrobromide;AKOS005146237;AC-2598;CS-W004131;FG-0490;HY-W004131;NSC-338478;SB37338;3-(bromomethyl)pyridine monohydrobromide;3-(bromomethyl)pyridine hydrogen bromide;3-(bromomethyl)pyridine hydrobromide salt;SY002302;3-(Bromomethyl)pyridine hydrobromide, 97%;AM20061249;B2170;FT-0651276;EN300-44247;3-(Bromomethyl)pyridine--hydrogen bromide (1/1);A871837

Chemical Property of 3-(Bromomethyl)pyridine hydrobromide

Chemical Property:

• Vapor Pressure: 0.00627mmHg at 25°C
• Melting Point: 150-155 °C(lit.)
• Boiling Point: 265.2 °C at 760 mmHg
• Flash Point: 114.2 °C
• PSA: 12.89000
• LogP: 2.93460
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 252.89247
• Heavy Atom Count: 9
• Complexity: 65.5

Purity/Quality:

99% ^*data from raw suppliers

3-(Bromomethyl)pyridine Hydrobromide >98.0%(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 22-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CN=C1)CBr.Br
• Uses: 3-(Bromomethyl)pyridine hydrobromide may be used in the preparation of ether ligands.

Technology Process of 3-(Bromomethyl)pyridine hydrobromide

There total 2 articles about 3-(Bromomethyl)pyridine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-hydroxymethylpyridin (100-55-0) → 3-(bromomethyl)pyridine hydrobromide (4916-55-6)

Guidance literature:

With hydrogen bromide; at 125 ℃; for 5h;

DOI:10.1039/b500667h

Reference yield:

methyl 3-pyridinecarboxylate (93-60-7) → 3-(bromomethyl)pyridine hydrobromide (4916-55-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / LiAlH₄ / diethyl ether / 4 h / Ambient temperature

2: 80 percent / aq. HBr / 4 h / Heating

With lithium aluminium tetrahydride; hydrogen bromide; In diethyl ether;

Reference yield: 89.0%

3-hydroxy-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)benzamide + 3-(bromomethyl)pyridine hydrobromide (4916-55-6) → N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-3-(pyridin-3-ylmethoxy)benzamide

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 - 65 ℃; for 3.5h;

upstream raw materials:

3-hydroxymethylpyridin

methyl 3-pyridinecarboxylate

Downstream raw materials:

6-methyl-2-((pyridin-3-yl)methylthio)pyrimidin-4-ol

5-methoxy-2-(4-methoxymethoxy-3,5-dimethylphenyl)-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one

2-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one

3-Methylpyridine

Refernces

• 1、 -. "PIPERIDINONES USEFUL IN THE TREATMENT OF INFLAMMATION". Page/Page column 112. . Retrieved 2008/12/07.
• 2、 Jokela, Reija,Tamminen, Tarja,Lounasmaa, Mauri. "13C NMR SPECTRAL AND STEREOCHEMICAL ANALYSIS OF PIPERIDINE DERIVED α-AMINONITRILES". . p. 1707 - 1722. Retrieved 2007/10/02.