1-Ethoxynaphthalene

Base Information

• Chemical Name: 1-Ethoxynaphthalene
• CAS No.: 5328-01-8
• Molecular Formula: C12H12O
• Molecular Weight: 172.227
• Hs Code.: 29093090
• European Community (EC) Number: 226-213-0
• NSC Number: 4174
• UNII: KPT9T4S9QZ
• DSSTox Substance ID: DTXSID30201402
• Nikkaji Number: J102.377B
• Wikidata: Q72471828
• Mol file: 5328-01-8.mol

Synonyms:1-ETHOXYNAPHTHALENE;5328-01-8;Naphthalene, 1-ethoxy-;Ethyl 1-naphthyl ether;1-Ehoxynaphthalene;Naphthalene, ethoxy-;.alpha.-Ethoxynaphthalene;alpha-Ethoxynaphthalene;Ethyl alpha-naphthyl ether;KPT9T4S9QZ;Ethyl .alpha.-naphthyl ether;NSC-4174;ethoxynaphthalene;UNII-KPT9T4S9QZ;SCHEMBL45343;DTXSID30201402;NSC4174;CHEBI:167813;NSC 4174;EINECS 226-213-0;GEO-01305;MFCD00003928;AKOS002945485;AI3-00179;CS-0197266;E0532;FT-0607731;EN300-52462;D90537;W-200054;Z55021536

Chemical Property of 1-Ethoxynaphthalene

Chemical Property:

• Appearance/Colour: Clear yellow to brown liquid
• Vapor Pressure: 0.00641mmHg at 25°C
• Melting Point: 5.5°C
• Refractive Index: 1.604
• Boiling Point: 280.5 °C at 760 mmHg
• Flash Point: 109.4 °C
• PSA: 9.23000
• Density: 1.049 g/cm³
• LogP: 3.23850
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 172.088815002
• Heavy Atom Count: 13
• Complexity: 155

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Ethoxynaphthalene >95.0%(GC) ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25-25-24

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC2=CC=CC=C21

Technology Process of 1-Ethoxynaphthalene

There total 27 articles about 1-Ethoxynaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.7%

α-naphthol (90-15-3) + ethyl iodide (75-03-6) → 1-ethoxynaphthalene (5328-01-8)

Guidance literature:

With potassium hydroxide; 18-crown-6 immobilized on 2-vinylpyridine-styrene copolymer; In chloroform; for 6h; Heating;

Reference yield: 85.0%

diethyl sulfate (64-67-5) + α-naphthol (90-15-3) → 1-ethoxynaphthalene (5328-01-8)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1016/S0040-4039(98)00885-5

Reference yield: 74.0%

α-naphthol (90-15-3) + boron trifluoride diethyl etherate (109-63-7) → 1-ethoxynaphthalene (5328-01-8)

Guidance literature:

at 120 ℃; for 4h; Reflux;

DOI:10.3390/molecules24203720

upstream raw materials:

ethyl bromide

α-naphthol

diethyl sulfate

sodium naphtholate

Downstream raw materials:

ethyl-(4-nitro-[1]naphthyl)-ether

ethyl-(2-nitro-[1]naphthyl)-ether

4-bromo-1-ethoxynaphthalene

ethyl-(4-iodo-[1]naphthyl)-ether

Refernces

• 1、 Jumbam, Ndze Denis,Maganga, Yamkela,Masamba, Wayiza,Mbunye, Nomthandazo I.,Mgoqi, Esethu,Mtwa, Sphumusa. "A new alkylation of aryl alcohols by boron trifluoride etherate". . . Retrieved 2019/10/28.
• 2、 Balint, Erika,Kovacs, Orsolya,Drahos, Laszlo,Keglevich, Gyoergy. "Microwave-Assisted solid-liquid phase alkylation of naphthols". . p. 330 - 336. Retrieved 2013/07/26.