4-Acetyl-4-bromobutyric acid methyl ester

Base Information

• Chemical Name: 4-Acetyl-4-bromobutyric acid methyl ester
• CAS No.: 64037-74-7
• Molecular Formula: C₇H₁₁BrO₃
• Molecular Weight: 223.067
• Hs Code.: 2918300090
• Mol file: 64037-74-7.mol

Synonyms:Methyl-4-brom-6-oxohexanat;Bromacetopropylacetate;BUTYRIC ACID,4-ACETYL-4-BROMO-,METHYL ESTER;

Chemical Property of 4-Acetyl-4-bromobutyric acid methyl ester

Chemical Property:

• Vapor Pressure: 0.00699mmHg at 25°C
• Boiling Point: 270.1°Cat760mmHg
• Flash Point: 117.1°C
• PSA: 43.37000
• Density: 1.409g/cm³
• LogP: 1.29210

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Acetyl-4-bromobutyric acid methyl ester

There total 2 articles about 4-Acetyl-4-bromobutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

methyl levulinate (13984-50-4) → methyl 4-bromo-5-oxohexanoate (64037-74-7)

Guidance literature:

With bromine; In diethyl ether; at 0 - 20 ℃;

DOI:10.1016/j.tet.2006.09.079

Reference yield:

→ methyl 4-bromo-5-oxohexanoate (64037-74-7)

Guidance literature:

aus Hexansaeure + CH2N2;

Reference yield:

methyl 4-bromo-5-oxohexanoate (64037-74-7) → 3-benzyl-4-[2-bromo-3-(tert-butyl-dimethyl-silanyloxy)-butyl]-2,3,3a,4,5,7-hexahydro-1H-pyrrolo[2,3-d]carbazole-6-carboxylic acid methyl ester

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / sodium borohydride / methanol / 0 - 20 °C

2: 78 percent / imidazole / CH₂Cl₂ / 24 h / Heating

3: 72 percent / diisobutyl aluminum hydride / CH₂Cl₂; hexane / 0.75 h / -60 °C

4: 47 percent / p-toluenesulfonic acid monohydrate / toluene / 24 h / Heating

With 1H-imidazole; sodium tetrahydroborate; diisobutylaluminium hydride; toluene-4-sulfonic acid; In methanol; hexane; dichloromethane; toluene;

DOI:10.1016/j.tet.2006.09.079

upstream raw materials:

methyl levulinate

Refernces