Glycine, N-(phenylmethyl)-, butyl ester

Base Information

• Chemical Name: Glycine, N-(phenylmethyl)-, butyl ester
• CAS No.: 92685-82-0
• Molecular Formula: C13H19NO2
• Molecular Weight: 221.299
• Mol file: 92685-82-0.mol

Synonyms:

Chemical Property of Glycine, N-(phenylmethyl)-, butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Glycine, N-(phenylmethyl)-, butyl ester

There total 3 articles about Glycine, N-(phenylmethyl)-, butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methyl 2-(benzylamino)acetate (53386-64-4) + butan-1-ol (71-36-3) → n-butyl N-benzylglycinoate (92685-82-0)

Guidance literature:

With C₁₂H₆F₁₈O₁₃Zn₄; In di-isopropyl ether; for 18h; Reflux; Inert atmosphere;

DOI:10.1055/s-0031-1290096

Reference yield:

butyl chloroacetate (590-02-3) + benzylamine (100-46-9) → n-butyl N-benzylglycinoate (92685-82-0)

Guidance literature:

With triethylamine; In diethyl ether;

DOI:10.1021/jo01075a014

Reference yield:

n-butyl bromoacetate (18991-98-5) + benzylamine (100-46-9) → n-butyl N-benzylglycinoate (92685-82-0)

Guidance literature:

upstream raw materials:

n-butyl bromoacetate

benzylamine

butyl chloroacetate

methyl 2-(benzylamino)acetate

Refernces

• 1、 Parmar, Narsidas J.,Pansuriya, Bhavesh R.,Labana, Balvantsingh M.,Kant, Rajni,Gupta, Vivek K.. "A convenient 1,3-dipolar cycloaddition-reduction synthetic sequence from 2-allyloxy-5-nitro-salicylaldehyde to aminobenzopyran-annulated heterocycles". . p. 17527 - 17539. Retrieved 2013/09/24.
• 2、 Maegawa, Yusuke,Agura, Kazushi,Hayashi, Yukiko,Ohshima, Takashi,Mashima, Kazushi. "Transesterification of α-amino esters catalyzed by a tetranuclear zinc cluster: Zn4(OCOCF3)6O". supporting information; experimental part. p. 137 - 141. Retrieved 2012/02/03.