OLANZAPINE N-OXIDE

Base Information

• Chemical Name: OLANZAPINE N-OXIDE
• CAS No.: 174794-02-6
• Molecular Formula: C₁₇H₂₀N₄OS
• Molecular Weight: 328.438
• Hs Code.: 29349990
• Mol file: 174794-02-6.mol

Synonyms:LY 170238;Olanzapine-N-oxide

Chemical Property of OLANZAPINE N-OXIDE

Chemical Property:

• Melting Point: 214-216°C (dec.)
• PKA: 7.32±0.20(Predicted)
• PSA: 75.50000
• LogP: 2.92210
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

NLT 98% ^*data from raw suppliers

OlanzapineN-Oxide ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Olanzapine (Olanzapine EP Impurity D).

Technology Process of OLANZAPINE N-OXIDE

There total 6 articles about OLANZAPINE N-OXIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.1%

zyprexa (132539-06-1) → Olanzapine N-Oxide (174794-02-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 12 ℃; for 12h;

Reference yield:

1-methyl-piperazine (109-01-3) → Olanzapine N-Oxide (174794-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene; dimethylsulfoxide

2: m-CPBA / CH₂Cl₂

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; dimethyl sulfoxide; toluene;

DOI:10.1016/S0960-894X(96)00567-7

Reference yield:

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → Olanzapine N-Oxide (174794-02-6)

Guidance literature:

Multi-step reaction with 4 steps

1: LiOH / dimethylsulfoxide

2: SnCl₂ / ethanol

3: toluene; dimethylsulfoxide

4: m-CPBA / CH₂Cl₂

With lithium hydroxide; 3-chloro-benzenecarboperoxoic acid; tin(ll) chloride; In ethanol; dichloromethane; dimethyl sulfoxide; toluene;

DOI:10.1016/S0960-894X(96)00567-7

upstream raw materials:

zyprexa

1-methyl-piperazine

ortho-nitrofluorobenzene

2-(2-nitroanilino)-5-methylthiophene-3-carbonitrile

Downstream raw materials:

zyprexa

(E)-3-phenylpropenal

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF OLANZAPINE". Page/Page column 27-29. . Retrieved 2008/06/13.