2-FLUOROCUMENE

Base Information

• Chemical Name: 2-FLUOROCUMENE
• CAS No.: 2022-67-5
• Molecular Formula: C9H11 F
• Molecular Weight: 138.185
• Hs Code.: 2903999090
• Mol file: 2022-67-5.mol

Synonyms:Cumene,o-fluoro- (7CI,8CI); 1-Fluoro-2-isopropylbenzene; o-Fluorocumene;o-Isopropylfluorobenzene

Chemical Property of 2-FLUOROCUMENE

Chemical Property:

• Vapor Pressure: 6.47mmHg at 25°C
• Boiling Point: 144.2°C at 760 mmHg
• Flash Point: 30.6°C
• PSA: 0.00000
• Density: 0.961g/cm³
• LogP: 2.94910

Purity/Quality:

98.5% ^*data from raw suppliers

2-FLUOROCUMENE 95.00% ^*data from reagent suppliers

Safty Information:

• Statements: 10
• Safety Statements: 16

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUOROCUMENE

There total 7 articles about 2-FLUOROCUMENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

isopropylboronic acid (80041-89-0) + 1-chloro-2-fluorobenzene (348-51-6) → 1-fluoro-2-iso-propylbenzene (2022-67-5)

Guidance literature:

With bis[1-methylnaphthylpalladium(II) bromide]; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In water; toluene; at 80 ℃; for 11h;

DOI:10.1002/anie.202110450

Reference yield:

potassium trifluoro(3-isopropylphenyl)borate → 1-fluoro-2-iso-propylbenzene (2022-67-5) + 1-fluoro-4-isopropylbenzene (403-39-4)

Guidance literature:

With iron(III) chloride; potassium fluoride; Selectfluor; In ethyl acetate; at 55 ℃; Overall yield = 65 %Spectr.;

DOI:10.1055/s-0034-1379942

Reference yield:

Isopropylbenzene (98-82-8) → 1-fluoro-2-iso-propylbenzene (2022-67-5) + 1-fluoro-3-isopropylbenzene (2193-38-6) + 1-fluoro-4-isopropylbenzene (403-39-4)

Guidance literature:

With lead(IV) acetate; boron trifluoride diethyl etherate; mercury(II) diacetate; Ambient temperature;

DOI:10.1016/S0040-4020(01)88032-7

upstream raw materials:

Isopropylbenzene

fluorobenzene

propane

2-isopropylaniline

Downstream raw materials:

2,2,2-trifluoro-1-(2-fluoro-3-isopropylphenyl)ethan-1-one

2'-Fluoroacetophenone

2-(2'-fluorophenyl)propan-2-ol

Refernces

• 1、 Doppiu, Angelino,Goo?en, Lukas J.,Hu, Zhiyong,Pirkl, Nico,Sivendran, Nardana. "Halogen-Bridged Methylnaphthyl Palladium Dimers as Versatile Catalyst Precursors in Coupling Reactions". supporting information. p. 25151 - 25160. Retrieved 2021/10/19.
• 2、 Mohy El Dine, Tharwat,Sadek, Omar,Gras, Emmanuel,Perrin, David M.. "Expanding the Balz–Schiemann Reaction: Organotrifluoroborates Serve as Competent Sources of Fluoride Ion for Fluoro-Dediazoniation". supporting information. p. 14933 - 14937. Retrieved 2018/09/25.