Pentanoic acid, 4-cyano-4-[(phenylthioxomethyl)thio]-, 3-azidopropyl ester

Base Information

• Chemical Name: Pentanoic acid, 4-cyano-4-[(phenylthioxomethyl)thio]-, 3-azidopropyl ester
• CAS No.: 927816-04-4
• Molecular Formula: C16H18N4O2S2
• Molecular Weight: 362.477
• Mol file: 927816-04-4.mol

Synonyms:

Chemical Property of Pentanoic acid, 4-cyano-4-[(phenylthioxomethyl)thio]-, 3-azidopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pentanoic acid, 4-cyano-4-[(phenylthioxomethyl)thio]-, 3-azidopropyl ester

There total 1 articles about Pentanoic acid, 4-cyano-4-[(phenylthioxomethyl)thio]-, 3-azidopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.6%

3-azidopropan-1-ol (72320-38-8) + 4-cyano-4-(thiobenzoylthio)pentanoic acid (201611-92-9) → 3-azidopropyl 4-cyano-4-(phenylcarbonothioylthio)pentanoate (927816-04-4)

Guidance literature:

4-cyano-4-(thiobenzoylthio)pentanoic acid; With dmap; In dichloromethane; for 0.0833333h; Cooling with ice;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 0.5h; Cooling with ice;

3-azidopropan-1-ol; In dichloromethane; at 20 ℃; for 8.5h; Cooling with ice;

Reference yield: 34.0%

3-azidopropyl 4-cyano-4-(phenylcarbonothioylthio)pentanoate (927816-04-4) + 1-ethynyl cobaltocenium hexafluorophosphate (131276-87-4) → C28H28CoN4O2S2(1+)*F6P(1-)

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; In tetrahydrofuran; water;

DOI:10.1021/jacs.1c05233

upstream raw materials:

3-azidopropan-1-ol

4-cyano-4-(thiobenzoylthio)pentanoic acid

Refernces

• 1、 Albuquerque, Lindomar J. C.,Giacomelli, Fernando C.,Heizer, Tomas,Hruby, Martin,Humajova, Jana,J?ger, Alessandro,J?ger, Eliézer,Janouskova, Olga,Konefa?, Rafa?,Kucka, Jan,Pankrac, Jan,Paral, Petr,Pavlova, Ewa,Pouckova, Pavla,Sedlacek, Ondrej,Sefc, Ludek,Sincari, Vladimir,Stepanek, Petr. "Reactive Oxygen Species (ROS)-Responsive Polymersomes with Site-Specific Chemotherapeutic Delivery into Tumors via Spacer Design Chemistry". . p. 1437 - 1449. Retrieved 2020/05/01.
• 2、 Mendon?a, Patrícia V.,Serra, Arménio C.,Popov, Anatoliy V.,Guliashvili, Tamaz,Coelho, Jorge F.J.. "Efficient RAFT polymerization of N-(3-aminopropyl)methacrylamide hydrochloride using unprotected "clickable" chain transfer agents". . p. 1 - 7. Retrieved 2014/05/20.