1-CHLORO-2,3,3-TRIFLUOROCYCLOBUTENE

Base Information

• Chemical Name: 1-CHLORO-2,3,3-TRIFLUOROCYCLOBUTENE
• CAS No.: 694-62-2
• Molecular Formula: C4H2 Cl F3
• Molecular Weight: 142.508
• Hs Code.: 2902190000
• Mol file: 694-62-2.mol

Synonyms:1-Chloro-2,3,3-trifluorocyclobutene

Chemical Property of 1-CHLORO-2,3,3-TRIFLUOROCYCLOBUTENE

Chemical Property:

• Vapor Pressure: 137mmHg at 25°C
• Refractive Index: n20/D 1.365(lit.)
• Boiling Point: 51-52 °C(lit.)
• Flash Point: 5 °F
• PSA: 0.00000
• Density: 1.355 g/mL at 25 °C(lit.)
• LogP: 2.44530
• Storage Temp.: Flammables area

Purity/Quality:

99% ^*data from raw suppliers

1-Chloro-2,3,3-trifluorocyclobutene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xn,Xi
• Hazard Codes: F,Xn,Xi
• Statements: 11-20/21/22-36/37
• Safety Statements: 16-26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 1-CHLORO-2,3,3-TRIFLUOROCYCLOBUTENE

There total 4 articles about 1-CHLORO-2,3,3-TRIFLUOROCYCLOBUTENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.5%

1,1,2-trichloro-2,3,3-trifluorocyclobutane (697-17-6) → 1-chloro-2,3,3,-trifluorocyclobutene (694-62-2)

Guidance literature:

In N,N-dimethyl-formamide; at 160 ℃; for 6h; Temperature; Autoclave;

Reference yield:

1,1,2-trichloro-2,3,3-trifluorocyclobutane (697-17-6) → 1-chloro-2,3,3,-trifluorocyclobutene (694-62-2) + 1,4-dichloro-3,3,4-trifluorocyclobutene (2927-72-2)

Guidance literature:

In N,N-dimethyl acetamide; at 170 ℃; for 6h; Solvent;

DOI:10.1016/j.jfluchem.2020.109506

Reference yield:

1,1,2,2-tetrachloro-3,3,4,4-tetrafluorocyclobutane (336-50-5) → 1-chloro-2,3,3,-trifluorocyclobutene (694-62-2)

Guidance literature:

Multistep reaction; (i) Zn, (ii) NaBH₄;

DOI:10.1021/jo00907a019

upstream raw materials:

1,1,2-trichloro-2,3,3-trifluorocyclobutane

1,1,2,2-tetrachloro-3,3,4,4-tetrafluorocyclobutane

Downstream raw materials:

1,1,2-trichloro-2,3,3-trifluorocyclobutane

2,2-difluorosuccinic acid

Refernces

• 1、 Guo, Qin,Lu, Fengniu,Quan, Hengdao,Zhang, Chengping,Zhang, Wenni. "Synthesis of hydrohalocyclobutenes through dechlorination of hydrohalocyclobutanes in amide solvents". . . Retrieved 2020.
• 2、 Akhtar,Botting,Cohen,Gani. "Enantiospecific synthesis of 3-substituted aspartic acids via enzymic amination of substituted fumaric acids". . p. 5899 - 5908. Retrieved 2007/10/02.