1H-Indole-2-pentanoic acid, 5-chloro-1-(phenylsulfonyl)-

Base Information

• Chemical Name: 1H-Indole-2-pentanoic acid, 5-chloro-1-(phenylsulfonyl)-
• CAS No.: 927961-06-6
• Molecular Formula: C19H18ClNO4S
• Molecular Weight: 391.875
• Mol file: 927961-06-6.mol

Synonyms:

Chemical Property of 1H-Indole-2-pentanoic acid, 5-chloro-1-(phenylsulfonyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Indole-2-pentanoic acid, 5-chloro-1-(phenylsulfonyl)-

There total 7 articles about 1H-Indole-2-pentanoic acid, 5-chloro-1-(phenylsulfonyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

methyl 5-[1-(benzenesulfonyl)-5-chloroindol-2-yl]pentanoate (927961-05-5) → 5-[1-(benzenesulfonyl)-5-chloroindol-2-yl]pentanoic acid (927961-06-6)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; for 3h;

DOI:10.1021/acs.jmedchem.7b01285

Reference yield: 79.0%

→ 5-[1-(benzenesulfonyl)-5-chloroindol-2-yl]pentanoic acid (927961-06-6)

Guidance literature:

Reference yield:

methyl 7-[2-(benzenesulfonamido)-5-chlorophenyl]hept-6-ynoate (927963-03-9) → 5-[1-(benzenesulfonyl)-5-chloroindol-2-yl]pentanoic acid (927961-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1: copper diacetate / 1,2-dichloro-ethane / 24 h / Reflux

2: lithium hydroxide monohydrate / water; tetrahydrofuran / 3 h / 20 °C

With lithium hydroxide monohydrate; copper diacetate; In tetrahydrofuran; water; 1,2-dichloro-ethane;

DOI:10.1021/acs.jmedchem.7b01285

upstream raw materials:

methyl 7-[2-(benzenesulfonamido)-5-chlorophenyl]hept-6-ynoate

7-(5-Chloro-2-nitrophenyl)-6-heptynoic acid methyl ester

methyl 5-[1-(benzenesulfonyl)-5-chloroindol-2-yl]pentanoate

methyl 7-(2-amino-5-chlorophenyl)hept-6-ynoate

Refernces

• 1、 -. "Indole Compounds, Method of Preparing Them and Uses Thereof". Page/Page column 33. . Retrieved 2008/12/06.