2-Chloro-4-nitrobenzene-1-sulfonyl chloride

Base Information

• Chemical Name: 2-Chloro-4-nitrobenzene-1-sulfonyl chloride
• CAS No.: 20201-03-0
• Molecular Formula: C6H3 Cl2 N O4 S
• Molecular Weight: 256.066
• Hs Code.: 2904909090
• European Community (EC) Number: 864-083-2
• NSC Number: 140589
• DSSTox Substance ID: DTXSID40301023
• Wikidata: Q82044542
• Mol file: 20201-03-0.mol

Synonyms:20201-03-0;2-Chloro-4-nitrobenzene-1-sulfonyl chloride;2-chloro-4-nitrobenzenesulfonyl chloride;2-Chloro-4-nitro-benzenesulfonyl chloride;MFCD03954008;Benzenesulfonyl chloride, 2-chloro-4-nitro-;NSC140589;GLYCYL-L-GLUTAMICACID;SCHEMBL1817485;DTXSID40301023;QWNVNPSFHISUID-UHFFFAOYSA-N;AKOS000199884;CS-W005795;DS-2610;NSC-140589;SY107090;2-Chloro-4-nitrobenzene-1-sulfonylchloride;FT-0717075;EN300-05539;A851478;2-chloro-4-nitro-benzenesulfonyl chloride, AldrichCPR

Chemical Property of 2-Chloro-4-nitrobenzene-1-sulfonyl chloride

Chemical Property:

• Vapor Pressure: 2.39E-05mmHg at 25°C
• Melting Point: 66-67 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 370.3°Cat760mmHg
• Flash Point: 177.7°C
• PSA: 88.34000
• Density: 1.708g/cm³
• LogP: 3.77970
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 254.9159841
• Heavy Atom Count: 14
• Complexity: 320

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-4-nitrobenzene-1-sulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=C(C=C1[N+](=O)[O-])Cl)S(=O)(=O)Cl

Technology Process of 2-Chloro-4-nitrobenzene-1-sulfonyl chloride

There total 2 articles about 2-Chloro-4-nitrobenzene-1-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Chloro-4-nitroaniline (121-87-9) → 2-chloro-4-nitrobenzenesulfonyl chloride (20201-03-0)

Guidance literature:

Multistep reaction; (i) (diazotization), (ii) aq. AcOH, SO₂, CuCl₂, NaNO₃;

Reference yield:

→ 2-chloro-4-nitrobenzenesulfonyl chloride (20201-03-0)

Guidance literature:

1-Amino-2-chlor-4-nitrobenzol: 1) Diazotierung mit 30percentiger HCl, NaNO2 2) 30percentige HCl, Cu-sulfat, Na-bisulfit;

Reference yield: 87.0%

2-chloro-4-nitrobenzenesulfonyl chloride (20201-03-0) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(2-chloro-4-nitro-phenyl)sulfonylpiperazine-1-carboxylate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

2-Chloro-4-nitroaniline

Downstream raw materials:

1,2-bis(2-chloro-4-nitrophenyl)disulfane

2-chloro-N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-4-nitrobenzenesulfonamide

4-amino-2-chloro-N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)benzenesulfonamide

Refernces

• 1、 PETROW,STEPHENSON,WILD. "Studies in the field of diuretic agents. V. A new route to disulphamyl derivatives of benzene.". . p. 705 - 719. Retrieved 2007/10/04.