Molindone hydrochloride

Base Information

• Chemical Name: Molindone hydrochloride
• CAS No.: 15622-65-8
• Molecular Formula: C₁₆H₂₄N₂O₂*ClH
• Molecular Weight: 312.84
• Hs Code.: 2934990002
• European Community (EC) Number: 633-875-8
• UNII: 1DWS68PNE6
• DSSTox Substance ID: DTXSID5045417
• Wikidata: Q27252301
• NCI Thesaurus Code: C47624
• RXCUI: 82051
• ChEMBL ID: CHEMBL1200419
• Mol file: 15622-65-8.mol

Synonyms:Hydrochloride, Molindone;Moban;Molindone;Molindone Hydrochloride;Molindone Monohydrochloride;Monohydrochloride, Molindone

Chemical Property of Molindone hydrochloride

Chemical Property:

• Vapor Pressure: 9.51E-09mmHg at 25°C
• Melting Point: 211-213°C
• Boiling Point: 462.9 °C at 760 mmHg
• Flash Point: 233.7 °C
• PSA: 45.33000
• LogP: 2.70270
• Storage Temp.: Refrigerator
• Solubility.: H2O: soluble19mg/mL
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 312.1604557
• Heavy Atom Count: 21
• Complexity: 354

Purity/Quality:

98%,99%, ^*data from raw suppliers

Molindone hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCC1=C(NC2=C1C(=O)C(CC2)CN3CCOCC3)C.Cl
• Uses: D2 Dopamine receptor antagonist. MAO inhibitor. Antipsychotic. Antipsychotic;Dopamine receptor antagonist
• Therapeutic Function: Antipsychotic

Technology Process of Molindone hydrochloride

There total 8 articles about Molindone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.48%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + morpholin hydrochloride (10024-89-2) + 3-ethyl-2-methyl-4-oxo-1H-4,5,6,7-tetrahydroindole (6116-76-3) → molindone hydrochloride (15622-65-8)

Guidance literature:

With hydrogenchloride; In methanol; water; at 50 - 55 ℃; for 6.25h; pH=3.5 - 3.8; Temperature; Solvent;

Reference yield: 73.96%

N-hydroxymethylmorpholine (4432-43-3) + 3-ethyl-2-methyl-4-oxo-1H-4,5,6,7-tetrahydroindole (6116-76-3) → molindone hydrochloride (15622-65-8)

Guidance literature:

N-hydroxymethylmorpholine; 3-ethyl-2-methyl-4-oxo-1H-4,5,6,7-tetrahydroindole; With acetic acid; at 64 - 67 ℃; for 7.5h;

With hydrogenchloride; In water;

Reference yield:

morpholine (110-91-8,99108-56-2) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-ethyl-2-methyl-4-oxo-1H-4,5,6,7-tetrahydroindole (6116-76-3) → molindone hydrochloride (15622-65-8)

Guidance literature:

morpholine; formaldehyd; 3-ethyl-2-methyl-4-oxo-1H-4,5,6,7-tetrahydroindole; In ethanol; at 75 - 80 ℃; for 0.24h;

With hydrogenchloride; In isopropyl alcohol; at 25 - 30 ℃; for 0.5h;

upstream raw materials:

1,3-cylohexanedione

formaldehyd

morpholin hydrochloride

3-ethyl-2-methyl-4-oxo-1H-4,5,6,7-tetrahydroindole

Refernces

• 1、 -. "Improved synthesizing method of molindone". Paragraph 0039-0048. . Retrieved 2017/09/01.