2-AMINO-3,3-DIPHENYL-PROPIONIC ACID

Base Information

• Chemical Name: 2-AMINO-3,3-DIPHENYL-PROPIONIC ACID
• CAS No.: 62653-26-3
• Molecular Formula: C15H15NO2
• Molecular Weight: 241.29
• Hs Code.: 2922499990
• Mol file: 62653-26-3.mol

Synonyms:Alanine,3,3-diphenyl- (6CI,7CI);NSC 13903;

Chemical Property of 2-AMINO-3,3-DIPHENYL-PROPIONIC ACID

Chemical Property:

• Vapor Pressure: 9.35E-07mmHg at 25°C
• Melting Point: 236 °C (decomp)
• Refractive Index: 1.611
• Boiling Point: 389.2 °C at 760 mmHg
• PKA: 2.11±0.10(Predicted)
• Flash Point: 189.2 °C
• PSA: 63.32000
• Density: 1.198g/cm³
• LogP: 2.93070
• Storage Temp.: Store at RT.

Purity/Quality:

99%+, ^*data from raw suppliers

Phenylalanine,?-phenyl- 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-3,3-DIPHENYL-PROPIONIC ACID

There total 6 articles about 2-AMINO-3,3-DIPHENYL-PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-(diphenylmethyl)imidazolidine-2,4-dione (270078-91-6) → 2-amino-3,3-diphenylpropionic acid (62653-26-3)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In water; for 18h; Heating;

DOI:10.1246/bcsj.73.681

Reference yield:

→ 2-amino-3,3-diphenylpropionic acid (62653-26-3)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01145a022

Reference yield:

Diphenylacetaldehyde (947-91-1) → 2-amino-3,3-diphenylpropionic acid (62653-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / ethanol; H₂O / 8 h / 50 °C

2: 99 percent / NaOH; hydrochloric acid / H₂O / 18 h / Heating

With hydrogenchloride; sodium hydroxide; In ethanol; water; 1: Condensation / 2: Hydrolysis;

DOI:10.1246/bcsj.73.681

upstream raw materials:

hydrogen iodide

acetic anhydride

5-(diphenylmethyl)imidazolidine-2,4-dione

Diphenylacetaldehyde

Downstream raw materials:

2,2-Diphenylethylamine

2-(9H-fluoren-9-ylmethoxycarbonylamino)-3,3-diphenyl-propionic acid

(S)-β,β-diphenyl-α-alanine

(2R)-3,3-diphenylalanine

Refernces

• 1、 -. "Substituted quinoxaline-2-ones as glutamate receptor antagonists". . . Retrieved 2008/06/13.
• 2、 -. "Process for the preparation of D(-) and L(+)-3,3-diphenylalanine and D(-) and L(+)-substituted 3,3-diphenylalanines and derivatives thereof". . . Retrieved 2008/06/13.