Dimethyl 2,4-pyridinedicarboxylate

Base Information

• Chemical Name: Dimethyl 2,4-pyridinedicarboxylate
• CAS No.: 25658-36-0
• Molecular Formula: C9H9 N O4
• Molecular Weight: 195.1721
• Hs Code.: 2933399090
• Mol file: 25658-36-0.mol

Synonyms:2,4-Pyridinedicarboxylicacid, dimethyl ester (6CI,7CI,8CI,9CI); 2,4-Bismethoxycarbonylpyridine;Dimethyl 2,4-pyridinedicarboxylate; NSC 78960

Chemical Property of Dimethyl 2,4-pyridinedicarboxylate

Chemical Property:

• Vapor Pressure: 0.000984mmHg at 25°C
• Melting Point: 252-253 °C(Solv: water (7732-18-5))
• Boiling Point: 302.5°Cat760mmHg
• PKA: -0.96±0.10(Predicted)
• Flash Point: 136.8°C
• PSA: 65.49000
• Density: 1.231g/cm³
• LogP: 0.65480
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

DimethylPyridine-2,4-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Dimethyl 2,4-pyridinedicarboxylate

There total 8 articles about Dimethyl 2,4-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + pyridine-2,4-dicarboxylic acid (499-80-9) → pyridine-2,4-dicarboxylic acid dimethyl ester (25658-36-0)

Guidance literature:

With thionyl chloride; for 5h; Reflux;

DOI:10.1016/j.bmc.2019.02.006

Reference yield: 63.0%

pyridine-2,4-dicarboxylic acid (499-80-9) + trimethyl orthoformate (149-73-5) → pyridine-2,4-dicarboxylic acid dimethyl ester (25658-36-0)

Guidance literature:

With sulfuric acid; In methanol; for 16h; Heating / reflux;

Reference yield:

methanol (67-56-1) + pyridine-2,4-dicarboxylic acid (499-80-9) → pyridine-2,4-dicarboxylic acid dimethyl ester (25658-36-0) + pyridine-2,4-dicarboxylic acid 2-methyl ester (24195-10-6)

Guidance literature:

With hydrogenchloride; at 50 ℃; for 8h; Inert atmosphere;

upstream raw materials:

diazomethane

pyridine-2,4-dicarboxylic acid

methanol

trimethyl orthoformate

Downstream raw materials:

2-carbamoylpyridine-4-carboxylic acid

Refernces

• 1、 Miyake, Yuka,Itoh, Yukihiro,Hatanaka, Atsushi,Suzuma, Yoshinori,Suzuki, Miki,Kodama, Hidehiko,Arai, Yoshinobu,Suzuki, Takayoshi. "Identification of novel lysine demethylase 5-selective inhibitors by inhibitor-based fragment merging strategy". . p. 1119 - 1129. Retrieved 2019/02/13.
• 2、 -. "Labelling reagents having a pyridine nucleus bearing a diazomethyl function, process for synthesis of such reagents and processes for detection of biological molecules". Page/Page column 12. . Retrieved 2016/03/13.