1-phenyl-1-aminomethylethene

Base Information

• Chemical Name: 1-phenyl-1-aminomethylethene
• CAS No.: 28144-67-4
• Molecular Formula: C9H11 N
• Molecular Weight: 133.193
• Hs Code.: 2921499090
• Mol file: 28144-67-4.mol

Synonyms:Phenethylamine,b-methylene- (8CI);2-Phenyl-2-propen-1-amine; 2-Phenylallylamine; 2-Propen-1-amine, 2-phenyl-;3-Amino-2-phenylpropene; MDL 72200; b-Methylenephenethylamine

Chemical Property of 1-phenyl-1-aminomethylethene

Chemical Property:

• Vapor Pressure: 0.11mmHg at 25°C
• Melting Point: 54-56 °C(Solv: hexane (110-54-3); ligroine (8032-32-4))
• Boiling Point: 220.9°Cat760mmHg
• PKA: 9.73±0.29(Predicted)
• Flash Point: 91.5°C
• PSA: 26.02000
• Density: 0.963g/cm³
• LogP: 2.35880

Purity/Quality:

99%, ^*data from raw suppliers

1-phenylprop-2-en-1-amine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-phenyl-1-aminomethylethene

There total 17 articles about 1-phenyl-1-aminomethylethene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

tert-butyl hydroxy(2-phenylallyl)carbamate (824950-51-8) → 2-phenylallylamine (28144-67-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.tetlet.2005.01.024

Reference yield: 37.0%

tert-Butyl N-hydroxycarbamate (36016-38-3) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → 2-phenylallylamine (28144-67-4)

Guidance literature:

With triethyl phosphite; copper(I) bromide; at 85 ℃;

DOI:10.1016/j.tetlet.2005.01.024

Reference yield:

N-Methoxycarbonyl-2-phenylallylamine (85278-15-5) → 2-phenylallylamine (28144-67-4) + chlorhydrate de l'amino-3 phenyl-2 propene (56132-76-4)

Guidance literature:

With trimethylsilyl iodide; In methanol; chloroform;

upstream raw materials:

2-hydroxy-2-phenyl-propionaldehyde-oxime

bromobenzene

1-(2-chloro-3-propenyl)-2,2,5,5-tetramethyl-2,5-disilazole

C₁₈H₂₃NO₃S₂Si

Downstream raw materials:

tert-butyl 2-phenylylallyl[(5-oxo-2,5-dihydrofuran-3-yl)methyl]carbamate

4-[(2-phenylallylamino)methyl]furan-2(5H)-one

5-(chloromethyl)-5-phenyloxazolidin-2-one

5-(chloromethyl)-5-phenyloxazolidin-2-one

Refernces

• 1、 Chen, Zhengkai,Du, Shiying,Song, Yufei,Wang, Le-Cheng,Wu, Xiao-Feng. "The cascade coupling/iodoaminocyclization reaction of trifluoroacetimidoyl chlorides and allylamines: metal-free access to 2-trifluoromethyl-imidazolines". . p. 6115 - 6119. Retrieved 2021/07/21.
• 2、 Qin, Tian,Jiang, Quanbin,Ji, Jieying,Luo, Jie,Zhao, Xiaodan. "Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines". supporting information. p. 1763 - 1766. Retrieved 2019/02/20.