Technology Process of D-Leucine,
N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl]-D-phenylalanyl]-, methyl
ester
There total 6 articles about D-Leucine,
N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl]-D-phenylalanyl]-, methyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
<((-)BPPM)Rh(norbornadiene)>(1+)*ClO4(1-);
In
ethanol;
at 40 ℃;
for 18h;
under 7600 Torr;
Yield given. Yields of byproduct given;
DOI:10.1016/S0040-4020(01)82412-1
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 96 percent / 1-hydroxybenzotriazole, N-methylmorpholine, N,N-dicyclohexylcarbodiimide / dimethylformamide / 2 h, 0 deg C then 12 h, 25 deg C
2: 96 percent / 1N NaOH / H2O; methanol / 2 h / 0 °C
3: 89 percent / NaOAc, Ac2O / 1 h, 0 deg C then 12 h, 25 deg C
4: Et3N / CHCl3
5: H2 / <(diPAMP)Rh(norbornadiene)>(1+)*ClO4(1-) / ethanol / 18 h / 40 °C / 7600 Torr
With
4-methyl-morpholine; sodium hydroxide; hydrogen; sodium acetate; acetic anhydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide;
<(diPAMP)Rh(norbornadiene)>(1+)*ClO4(1-);
In
methanol; ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)82412-1
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 96 percent / 1-hydroxybenzotriazole, N-methylmorpholine, N,N-dicyclohexylcarbodiimide / dimethylformamide / 2 h, 0 deg C then 12 h, 25 deg C
2: 96 percent / 1N NaOH / H2O; methanol / 2 h / 0 °C
3: 89 percent / NaOAc, Ac2O / 1 h, 0 deg C then 12 h, 25 deg C
4: Et3N / CHCl3
5: H2 / <(diPAMP)Rh(norbornadiene)>(1+)*ClO4(1-) / ethanol / 18 h / 40 °C / 7600 Torr
With
4-methyl-morpholine; sodium hydroxide; hydrogen; sodium acetate; acetic anhydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide;
<(diPAMP)Rh(norbornadiene)>(1+)*ClO4(1-);
In
methanol; ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)82412-1