2-chloro-N-(1,1-dimethyl-2-phenylethyl)acetamide

Base Information

• Chemical Name: 2-chloro-N-(1,1-dimethyl-2-phenylethyl)acetamide
• CAS No.: 26187-18-8
• Molecular Formula: C12H16 Cl N O
• Molecular Weight: 225.718
• Mol file: 26187-18-8.mol

Synonyms:Acetamide,2-chloro-N-(a,a-dimethylphenethyl)- (6CI,8CI)

Chemical Property of 2-chloro-N-(1,1-dimethyl-2-phenylethyl)acetamide

Chemical Property:

• Vapor Pressure: 3.86E-06mmHg at 25°C
• Boiling Point: 385.2°Cat760mmHg
• Flash Point: 186.8°C
• Density: 1.097g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-N-(1,1-dimethyl-2-phenylethyl)acetamide

There total 4 articles about 2-chloro-N-(1,1-dimethyl-2-phenylethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

chloroacetyl chloride (79-04-9) + Phentermin (122-09-8) → 2-chloro-N-(2-methyl-1-phenylpropan-2-yl)acetamide (26187-18-8)

Guidance literature:

With potassium carbonate; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00094a006

Reference yield: 78.0%

2-Methyl-1-phenyl-2-propanol (100-86-7) + chloroacetonitrile (107-14-2) → 2-chloro-N-(2-methyl-1-phenylpropan-2-yl)acetamide (26187-18-8)

Guidance literature:

With sulfuric acid; acetic acid; at 20 ℃; for 5h;

DOI:10.1055/s-2000-8208

Reference yield:

phenylacetic acid (103-82-2) → 2-chloro-N-(2-methyl-1-phenylpropan-2-yl)acetamide (26187-18-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 50 °C

2: tetrahydrofuran / 2 h / 0 - 25 °C

3: trifluoroacetic acid / 9 h / 50 °C

With sulfuric acid; trifluoroacetic acid; In tetrahydrofuran;

DOI:10.1021/ol503459s

upstream raw materials:

chloroacetyl chloride

Phentermin

2-Methyl-1-phenyl-2-propanol

chloroacetonitrile

Downstream raw materials:

Phentermin

N-(1,1-dimethyl-2-(4-nitrophenyl)ethyl)amine

C₁₇H₁₈N₂O₆

N-methyl-N-(1-methyl-hexyl)-glycine-(1,1-dimethyl-2-phenyl-ethylamide)

Refernces

• 1、 Yuan, Ming,Chen, Li,Wang, Junwei,Chen, Shenjie,Wang, Kongchao,Xue, Yongbo,Yao, Guangmin,Luo, Zengwei,Zhang, Yonghui. "Transition-metal-free synthesis of phenanthridinones from biaryl-2-oxamic acid under radical conditions". supporting information. p. 346 - 349. Retrieved 2015/02/19.
• 2、 Jirgensons,Kauss,Kalvinsh,Gold. "A practical synthesis of tert-alkylamines via the ritter reaction with chloroacetonitrile". . p. 1709 - 1712. Retrieved 2007/10/03.