5,6,7,8-Tetrahydro-2-naphthylamine

Base Information

• Chemical Name: 5,6,7,8-Tetrahydro-2-naphthylamine
• CAS No.: 2217-43-8
• Molecular Formula: C10H13N
• Molecular Weight: 147.22
• Hs Code.: 2921450090
• European Community (EC) Number: 218-714-8
• UNII: L25UNU8WNU
• DSSTox Substance ID: DTXSID30176702
• Nikkaji Number: J135.689E
• Wikidata: Q83046996
• Mol file: 2217-43-8.mol

Synonyms:2217-43-8;5,6,7,8-tetrahydronaphthalen-2-amine;5,6,7,8-Tetrahydro-2-naphthylamine;6-Aminotetralin;2-Naphthalenamine, 5,6,7,8-tetrahydro-;L25UNU8WNU;EINECS 218-714-8;MFCD00130046;2-Naphthylamine, 5,6,7,8-tetrahydro-;6-Amino-1,2,3,4-tetrahydronaphthalene;Tetralin-6-amine;2-Amino-5,6,7,8-tetrahydronaphthalene;UNII-L25UNU8WNU;SCHEMBL264473;DTXSID30176702;STK783528;1,2,3,4-Tetrahydro-6-naphthylamine;AKOS000145620;SB75458;5,6,7,8-Tetrahydro-2-naphthalenamine;AC-17557;AS-62985;SY102107;5,6,7,8-Tetrahydro-2-naphthalenamine #;5,6,7,8-tetrahydro-naphthalen-2-ylamine;5,6,7,8-Tetrahydro-2-naphthylamine, 96%;EN300-53382;A878662;J-014566;Z278204684;(5,6,7,8-Tetrahydronaphthalen-2-yl)amine, 2-Amino-5,6,7,8-tetrahydronaphthalene, 6-Amino-1,2,3,4-tetrahydronaphthalene, 6-Aminotetralin

Chemical Property of 5,6,7,8-Tetrahydro-2-naphthylamine

Chemical Property:

• Appearance/Colour: WHITE TO TAN TO GREEN POWDER, CRYSTALS,. CRYSTALLINE POWDER, SOLID AND/OR CHUNKS
• Vapor Pressure: 0.00225mmHg at 25°C
• Melting Point: 34-38 °C
• Refractive Index: 1.598
• Boiling Point: 289 °C at 760 mmHg
• PKA: 5.13±0.20(Predicted)
• Flash Point: 140.8 °C
• PSA: 26.02000
• Density: 1.062g/cm³
• LogP: 2.72880
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 147.104799419
• Heavy Atom Count: 11
• Complexity: 133

Purity/Quality:

98%,99%, ^*data from raw suppliers

5,6,7,8-tetrahydronaphthalen-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CCC2=C(C1)C=CC(=C2)N

Technology Process of 5,6,7,8-Tetrahydro-2-naphthylamine

There total 29 articles about 5,6,7,8-Tetrahydro-2-naphthylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

6-nitrotetralin (19353-86-7) → 6-amino-1,2,3,4-tetrahydronaphthalene (2217-43-8)

Guidance literature:

With palladium 10% on activated carbon; ammonium formate; silica gel; In methanol; for 1.5h; Milling;

DOI:10.3390/molecules23123163

Reference yield: 95.0%

naphthalen-2-ylamine (91-59-8) → 6-amino-1,2,3,4-tetrahydronaphthalene (2217-43-8)

Guidance literature:

With hydrogen; In ethanol; at 25 - 30 ℃;

Reference yield: 90.0%

6-amino-1-tetralone (3470-53-9) → 6-amino-1,2,3,4-tetrahydronaphthalene (2217-43-8)

Guidance literature:

With triethylsilane; trifluoroacetic acid; at 25 ℃; for 2h;

DOI:10.1021/jm049485i

upstream raw materials:

6-nitrotetralin

5-nitro-1,2,3,4-tetrahydronaphthalene

N-(naphthalen-2-yl)benzamide

2-acetylaminonaphthalene

Downstream raw materials:

N-(5,6,7,8-tetrahydro-[2]naphthyl)-anthranilic acid

1-(2-chloroethyl)-3-(5,6,7,8-tetrahydro-2-naphthyl)-urea

11-(3,5-dibromophenyl)-4,6,7,8,9,11-hexahydrobenzo[g]furo[3,4-b]quinolin-1(3H)-one

11-(3,4,5-trimethoxyphenyl)-4,6,7,8,9,11-hexahydrobenzo[g]furo[3,4-b]quinolin-1(3H)-one

Refernces

• 1、 Bastos, Gustavo A.,de Mattos, Marcio C.S.. "A convenient Hofmann reaction of carboxamides and cyclic imides mediated by trihaloisocyanuric acids". . . Retrieved 2021/09/29.
• 2、 Portada, Tomislav,Margeti?, Davor,?trukil, Vjekoslav. "Mechanochemical catalytic transfer hydrogenation of aromatic nitro derivatives". supporting information. . Retrieved 2018/12/11.