Droxicam

Base Information

• Chemical Name: Droxicam
• CAS No.: 90101-16-9
• Molecular Formula: C₁₆H₁₁N₃O₅S
• Molecular Weight: 357.346
• UNII: F24ADO1E2D
• DSSTox Substance ID: DTXSID70238035
• Nikkaji Number: J25.832F
• Wikipedia: Droxicam
• Wikidata: Q5308701
• NCI Thesaurus Code: C65492
• Metabolomics Workbench ID: 152249
• ChEMBL ID: CHEMBL1213420
• Mol file: 90101-16-9.mol

Synonyms:5-methyl-3-(2-pyridyl)-2H,5H-1,3-oxazino(5,6-c)(1,2)benzothiazine-2,4(3H)dione-6,6-dioxide;droxicam;E-3128

Chemical Property of Droxicam

Chemical Property:

• Vapor Pressure: 2.4E-12mmHg at 25°C
• Melting Point: 259-261°
• Boiling Point: 554.7°Cat760mmHg
• PKA: 3.80±0.19(Predicted)
• Flash Point: 289.3°C
• PSA: 110.86000
• Density: 1.68g/cm³
• LogP: 2.13700
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 1
• Exact Mass: 357.04194163
• Heavy Atom Count: 25
• Complexity: 741

Purity/Quality:

99% ^*data from raw suppliers

Droxicam ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C2=C(C3=CC=CC=C3S1(=O)=O)OC(=O)N(C2=O)C4=CC=CC=N4
• Description: Droxicam is an orally-active prodrug of piroxicam useful in the treatment of spinal osteoarthritis. Although it has a pharmacological profile comparable to piroxicam, droxicam's experimental ulcerogenic effect is ten times less. In animal studies droxicam is also reported to have analgesic and antipyretic activities, with no cardiovascular or respiratory effects.
• Uses: Droxicam is a non-steroidal anti-inflammatory drug.

Technology Process of Droxicam

There total 4 articles about Droxicam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

bis(trichloromethyl) carbonate (32315-10-9) + Piroxicam (36322-90-4) → droxicam (90101-16-9)

Guidance literature:

With triethylamine; In acetone; for 4h; Ambient temperature;

DOI:10.1002/prac.19973390185

Reference yield:

N-ethoxycarbonyl-N-(pyridin-2-yl)-4-ethoxy-carbonyloxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide → droxicam (90101-16-9)

Guidance literature:

In pyridine; water;

Reference yield:

→ droxicam (90101-16-9)

Guidance literature:

upstream raw materials:

bis(trichloromethyl) carbonate

Piroxicam

Refernces

• 1、 -. "Benzothiazine derivatives and their applications as medicinal products or as synthesis intermediates for medicinal products". . . Retrieved 2008/06/13.
• 2、 -. "Derivatives of oxazinobenzothiazine-6,6-dioxide". . . Retrieved 2008/06/13.