Technology Process of Bromfenac
There total 6 articles about Bromfenac which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
7-(4-bromobenzoyl)-1,3-dihydro-2H-indol-2-one;
With
sodium hydroxide;
In
water;
for 0.5h;
Reflux;
Autoclave;
With
acetic acid;
In
dichloromethane; water;
for 1h;
pH=6-7;
- Guidance literature:
-
2-ethanoylamino-5-sulfobenzenethanoic acid; 4-chlorobenzoyl chloride;
With
aluminum (III) chloride;
In
toluene;
at 10 - 30 ℃;
With
hydrogenchloride;
In
water;
Solvent;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide / dimethyl sulfoxide / 5 h / 25 - 30 °C
2.1: phosphoric acid / 2-methoxy-ethanol / 14 h / Reflux
3.1: sodium hydroxide / water / 0.5 h / Reflux; Autoclave
3.2: 1 h / pH 6-7
With
N-Bromosuccinimide; phosphoric acid; sodium hydroxide;
In
2-methoxy-ethanol; water; dimethyl sulfoxide;
