(2-broMo-6-Methoxyphenyl)Methanol

Base Information

• Chemical Name: (2-broMo-6-Methoxyphenyl)Methanol
• CAS No.: 93710-52-2
• Molecular Formula: C8H9BrO2
• Molecular Weight: 217.062
• Hs Code.: 2909498090
• Mol file: 93710-52-2.mol

Synonyms:2-bromo-6-methoxybenzylalcohol;(2-Bromo-6-methoxy-phenyl)-methanol;

Chemical Property of (2-broMo-6-Methoxyphenyl)Methanol

Chemical Property:

• Melting Point: 75 °C (methanol)
• PSA: 29.46000
• LogP: 1.95000

Purity/Quality:

95% ^*data from raw suppliers

2-Bromo-6-methoxybenzylAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Bromo-6-methoxybenzyl Alcohol is used in preparation of Pyrrolocarbazole derivatives for the treatment of Thrombopenia.

Technology Process of (2-broMo-6-Methoxyphenyl)Methanol

There total 4 articles about (2-broMo-6-Methoxyphenyl)Methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-bromo-6-methoxybenzaldehyde (126712-07-0) → (2-bromo-6-methoxyphenyl)methanol (93710-52-2)

Guidance literature:

2-bromo-6-methoxybenzaldehyde; With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h; Inert atmosphere;

With water; In methanol;

Reference yield: 91.0%

2-bromo-6-methoxybenzoic acid (31786-45-5) → (2-bromo-6-methoxyphenyl)methanol (93710-52-2)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 20 ℃; for 10h;

Reference yield:

ortho-anisaldehyde (135-02-4) → (2-bromo-6-methoxyphenyl)methanol (93710-52-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethanol / 24 h / 25 °C / Inert atmosphere

2.1: tert.-butyl lithium / diethyl ether; pentane / 8 h / -40 - -20 °C / Inert atmosphere

2.2: 12 h / 0 - 25 °C

2.3: 1 h / 0 °C

3.1: sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere

With sodium tetrahydroborate; tert.-butyl lithium; In methanol; diethyl ether; ethanol; pentane;

upstream raw materials:

2-bromo-6-methoxybenzoic acid

2-bromo-6-methoxybenzaldehyde

ortho-anisaldehyde

2-(2-methoxyphenyl)-1,3-dimethylimidazolidine

Downstream raw materials:

1-bromo-2-(bromomethyl)-3-methoxybenzene

C₁₂H₁₈BrO₄P

C₂₇H₂₃BrO₃

(E)-3-(2-(((tert-butyldimethylsilyl)oxy)methyl)-3-methoxyphenyl)acrylic acid

Refernces

• 1、 -. "SYNTHESIS OF THE POTENT IMMUNOSUPPRESSANT AGENTS DALESCONOL A AND B". Page/Page column 72-73. . Retrieved 2011/09/19.
• 2、 Theuns, Hubert G.,Lenting, Herman B. M.,Salemink, Cornelis A.,Tanaka, Hitoshi,Shibata, Masayoshi,et al.. "NEODIHYDROTHEBAINE AND BRACTAZONINE, TWO DIBENZAZONINE ALKALOIDS OF PAPAVER BRACTEATUM". . p. 1157 - 1166. Retrieved 2007/10/02.