Methanesulfonic acid, trifluoro-, 1-[[2-(1-propynyl)phenyl]methyl]ethenyl ester

Base Information

• Chemical Name: Methanesulfonic acid, trifluoro-, 1-[[2-(1-propynyl)phenyl]methyl]ethenyl ester
• CAS No.: 93769-04-1
• Molecular Formula: C₁₃H₁₁F₃O₃S
• Molecular Weight: 304.29
• Mol file: 93769-04-1.mol

Synonyms:

Chemical Property of Methanesulfonic acid, trifluoro-, 1-[[2-(1-propynyl)phenyl]methyl]ethenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid, trifluoro-, 1-[[2-(1-propynyl)phenyl]methyl]ethenyl ester

There total 9 articles about Methanesulfonic acid, trifluoro-, 1-[[2-(1-propynyl)phenyl]methyl]ethenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-iodophenyl)propan-2-one (21906-34-3) → 1-methylene-2-<2-(1-propyn-1-yl)phenyl>ethyl triflate (93769-04-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / bis(triphenylphosphane)palladium diacetate, NaOCH₃ / dimethylformamide / 3 h / 50 °C

2: 45 percent Spectr_. / 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂ / Ambient temperature

With 2,6-di-tert-butyl-4-methylpyridine; bis(triphenylphosphine) palladium (Il) acetate; sodium methylate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

o-iodophenylacetyl chloride (62300-07-6) → 1-methylene-2-<2-(1-propyn-1-yl)phenyl>ethyl triflate (93769-04-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / CuI / diethyl ether / 1 h / -78 °C

2: 80 percent / bis(triphenylphosphane)palladium diacetate, NaOCH₃ / dimethylformamide / 3 h / 50 °C

3: 45 percent Spectr_. / 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂ / Ambient temperature

With copper(l) iodide; 2,6-di-tert-butyl-4-methylpyridine; bis(triphenylphosphine) palladium (Il) acetate; sodium methylate; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

o-iodophenylacetic acid (18698-96-9) → 1-methylene-2-<2-(1-propyn-1-yl)phenyl>ethyl triflate (93769-04-1)

Guidance literature:

Multi-step reaction with 4 steps

1: SOCl₂

2: 67 percent / CuI / diethyl ether / 1 h / -78 °C

3: 80 percent / bis(triphenylphosphane)palladium diacetate, NaOCH₃ / dimethylformamide / 3 h / 50 °C

4: 45 percent Spectr_. / 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂ / Ambient temperature

With copper(l) iodide; thionyl chloride; 2,6-di-tert-butyl-4-methylpyridine; bis(triphenylphosphine) palladium (Il) acetate; sodium methylate; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

trifluoromethylsulfonic anhydride

1-<2-(1-Propin-1-yl)phenyl>-2-propanon

1-(2-iodophenyl)propan-2-one

o-iodophenylacetyl chloride

Downstream raw materials:

1-(1-Propin-1-yl)-2-(2-propin-1-yl)benzol

<(3-methyl-2-naphthyl)methyl>(2,2,2-trifluoroethyl)ether

(2,3-Dimethyl-1-naphthyl)-(2,2,2-trifluorethyl)-ether

Refernces