3,5-Pyridinedicarboxylic acid, 2-[[2-(acetylamino)ethoxy]methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-meth yl-, 3-ethyl 5-methyl ester

Base Information

• Chemical Name: 3,5-Pyridinedicarboxylic acid, 2-[[2-(acetylamino)ethoxy]methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-meth yl-, 3-ethyl 5-methyl ester
• CAS No.: 93848-82-9
• Molecular Formula: C22H27ClN2O6
• Molecular Weight: 450.919
• Mol file: 93848-82-9.mol

Synonyms:

Chemical Property of 3,5-Pyridinedicarboxylic acid, 2-[[2-(acetylamino)ethoxy]methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-meth yl-, 3-ethyl 5-methyl ester

Chemical Property:

Purity/Quality:

>95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-Pyridinedicarboxylic acid, 2-[[2-(acetylamino)ethoxy]methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-meth yl-, 3-ethyl 5-methyl ester

There total 2 articles about 3,5-Pyridinedicarboxylic acid, 2-[[2-(acetylamino)ethoxy]methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-meth yl-, 3-ethyl 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (88150-42-9) + acetyl chloride (75-36-5) → 2-<<2-(N-acetylamino)ethoxy>methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine (93848-82-9)

Guidance literature:

With pyridine; for 14h; Ambient temperature;

DOI:10.1021/jm00164a019

Reference yield:

2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (88150-42-9) + acetylcoenzyme A (72-89-9) → 2-<<2-(N-acetylamino)ethoxy>methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine (93848-82-9)

Guidance literature:

With triethanolamine; ethylenediaminetetraacetic acid; carnitine acetyltransferase; arylamine N-acetyltransferase 2*4, wild-type allele; acetylcarnitine; diothiothreitol; In water; at 37 ℃; for 18h; pH=7.5; Reagent/catalyst; Catalytic behavior; Enzymatic reaction;

DOI:10.1002/anie.202005915

Reference yield: 91.0%

2-<<2-(N-acetylamino)ethoxy>methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine (93848-82-9) → 2-[2-(acetylamino)ethoxymethyl]-3-ethoxycarbonyl-4-(o-chlorophenyl)-5-methoxycarbonyl-6-methylpyridine

Guidance literature:

With lead(IV) acetate; In dichloromethane; acetic acid; at 20 ℃; for 20h;

DOI:10.3987/COM-04-10194

upstream raw materials:

2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

acetyl chloride

acetylcoenzyme A

Refernces

• 1、 Alker, David,Campbell, Simon F.,Cross, Peter E.,Burges, Roger A.,Carter, Anthony J.,Gardiner, Donald G.. "Long-Acting Dihydropyridine Calcium Antagonists. 4. Synthesis and Structure-Activity Relationships for a Series of Basic and Nonbasic Derivatives of 2--1,4-dihydropyridine Calcium Antagonists". . p. 585 - 591. Retrieved 2007/10/02.