[[(2R,3R,4S,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan- 2-yl]methoxy-hydroxy-phosphoryl]oxy-[(2R)-2,3-dioctadecanoyloxypropoxy ]phosphinic acid

Base Information

• Chemical Name: [[(2R,3R,4S,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan- 2-yl]methoxy-hydroxy-phosphoryl]oxy-[(2R)-2,3-dioctadecanoyloxypropoxy ]phosphinic acid
• CAS No.: 83214-11-3
• Molecular Formula: C₄₈H₈₉N₃O₁₅P₂
• Molecular Weight: 1010.19
• Mol file: 83214-11-3.mol

Synonyms:

Chemical Property of [[(2R,3R,4S,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan- 2-yl]methoxy-hydroxy-phosphoryl]oxy-[(2R)-2,3-dioctadecanoyloxypropoxy ]phosphinic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 978.6°Cat760mmHg
• Flash Point: 545.7°C
• PSA: 285.11000
• Density: 1.24g/cm³
• LogP: 11.25450

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [[(2R,3R,4S,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan- 2-yl]methoxy-hydroxy-phosphoryl]oxy-[(2R)-2,3-dioctadecanoyloxypropoxy ]phosphinic acid

There total 2 articles about [[(2R,3R,4S,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan- 2-yl]methoxy-hydroxy-phosphoryl]oxy-[(2R)-2,3-dioctadecanoyloxypropoxy ]phosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

distearoylphosphatidylcholine (816-94-4,18603-43-5) → 1-β-D-arabinofuranosylcytosine 5'-diphosphate-L-1,2-distearin (83214-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.2 M NaOAc/AcOH, CaCl₂, sodium dodecyl sulfate (SDS) / diethyl ether / 240 h / 30 °C / phospholipase D

2: pyridine / 96 h

With pyridine; sodium acetate; sodium dodecyl-sulfate; acetic acid; calcium chloride; In diethyl ether;

DOI:10.1021/jm00353a010

Reference yield:

1,2-Distearoyl-sn-glycero-3-phosphoric acid (17966-16-4) + 1-β-D-arabinofuranosylcytosine 5'-monophosphomorpholidate 4-morpholino-N,N'-dicyclohexylcarboxamidinium salt → 1-β-D-arabinofuranosylcytosine 5'-diphosphate-L-1,2-distearin (83214-11-3)

Guidance literature:

With pyridine; for 96h;

DOI:10.1021/jm00353a010

upstream raw materials:

1,2-Distearoyl-sn-glycero-3-phosphoric acid

distearoylphosphatidylcholine

Refernces