6-n-propyluracil

Base Information

• Chemical Name: 6-n-propyluracil
• CAS No.: 13345-08-9
• Molecular Formula: C7H10 N2 O2
• Molecular Weight: 154.17
• Hs Code.: 2933599090
• Mol file: 13345-08-9.mol

Synonyms:Uracil,6-propyl- (6CI,7CI,8CI); 6-Propyl-2-uracil;6-Propylpyrimidine-2,4(1H,3H)-dione; 6-Propyluracil; 6-n-Propyluracil; NSC58559

Chemical Property of 6-n-propyluracil

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 65.72000
• Density: 1.126g/cm³
• LogP: 0.01570

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-n-propyluracil

There total 4 articles about 6-n-propyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

propylthiouracil (51-52-5) → 6-propyl(1H,3H)pyrimidine-2,4-dione (13345-08-9)

Guidance literature:

With chloroacetic acid; In water; for 5h; Heating;

DOI:10.1021/jm060848j

Reference yield: 83.0%

ethyl butyroyl acetate (3249-68-1) + urea (57-13-6) → 6-propyl(1H,3H)pyrimidine-2,4-dione (13345-08-9)

Guidance literature:

With boron trifluoride diethyl etherate; at 135 ℃; for 0.0833333h; Neat (no solvent); Microwave irradiation;

DOI:10.1016/j.tetlet.2012.03.056

Reference yield:

ethyl butyroyl acetate (3249-68-1) → 6-propyl(1H,3H)pyrimidine-2,4-dione (13345-08-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium ethoxide

2: chloroacetic acid / Heating

With sodium ethanolate; chloroacetic acid;

DOI:10.3891/acta.chem.scand.50-0417

upstream raw materials:

propylthiouracil

ethyl butyroyl acetate

urea

Downstream raw materials:

1,3-dimethyl-6-n-propyluracil

2-[(5-bromo-2-chloro-6-propylpyrimidin-4-yl)sulfanyl]aniline

2-(4-phenylpiperazin-1-yl)-4-propyl-pyrimido[4,5-b][1,4]benzothiazine

1-(7-chloro-1-phenyl-5-propyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-yl)-2-phenyldiazene

Refernces

• 1、 Nikpour, Mohsen,Mousavian, Mina,Davoodnejad, Mahdieh,Alimardani, Maliheh,Sadeghian, Hamid. "Synthesis of new series of pyrimido[4,5-b][1,4] benzothiazines as 15-lipoxygenase inhibitors and study of their inhibitory mechanism". . p. 5036 - 5043. Retrieved 2013/09/23.
• 2、 El-Tayeb, Ali,Qi, Aidong,Müller, Christa E.. "Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors". . p. 7076 - 7087. Retrieved 2007/10/03.