N,N-Diethyl-m-anisidine

Base Information

• Chemical Name: N,N-Diethyl-m-anisidine
• CAS No.: 92-18-2
• Molecular Formula: C11H17 N O
• Molecular Weight: 179.262
• European Community (EC) Number: 202-134-7
• DSSTox Substance ID: DTXSID9059044
• Nikkaji Number: J10.603H
• Wikidata: Q81988655
• Mol file: 92-18-2.mol

Synonyms:N,N-Diethyl-m-anisidine;92-18-2;N,N-diethyl-3-methoxyaniline;Benzenamine, N,N-diethyl-3-methoxy-;EINECS 202-134-7;3-diethylamino anisole;N,N-diethyl-m-anisidin;N,N-diethyl-3-anisidine;SCHEMBL2091361;DTXSID9059044;AKOS016005730;W-109340

Chemical Property of N,N-Diethyl-m-anisidine

Chemical Property:

• Vapor Pressure: 0.021mmHg at 25°C
• Boiling Point: 251.132°C at 760 mmHg
• Flash Point: 73.332°C
• Density: 0.972g/cm³
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 179.131014166
• Heavy Atom Count: 13
• Complexity: 134

Purity/Quality:

98%min ^*data from raw suppliers

N,N-Diethyl-3-methoxyaniline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)C1=CC(=CC=C1)OC

Technology Process of N,N-Diethyl-m-anisidine

There total 27 articles about N,N-Diethyl-m-anisidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-methoxy-1-iodobenzene (766-85-8) + diethylamine (109-89-7) → N,N-diethyl-3-methoxyaniline (92-18-2)

Guidance literature:

With potassium phosphate; copper(l) iodide; CVT-2537; In dimethyl sulfoxide; at 90 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol301135c

Reference yield: 93.0%

1-chloro-3-methoxy-benzene (2845-89-8) + diethylamine (109-89-7) → N,N-diethyl-3-methoxyaniline (92-18-2)

Guidance literature:

With potassium tert-butylate; In toluene; at 135 ℃; for 36h;

DOI:10.1021/jo001544m

Reference yield: 91.0%

methyl p-toluene sulfonate (80-48-8) + 3-diethylaminophenol (91-68-9) → N,N-diethyl-3-methoxyaniline (92-18-2)

Guidance literature:

3-diethylaminophenol; With sodium hydroxide; In acetonitrile; for 1h;

methyl p-toluene sulfonate; at 70 ℃;

DOI:10.1039/d0cc05133k

upstream raw materials:

1-bromo-4-methoxy-benzene

diethyl ether

lithium diethylamide

1-fluoro-2-methoxybenzene

Downstream raw materials:

2-[2-(4-Diethylamino-2-methoxy-phenylazo)-benzothiazol-6-yloxy]-ethanol

(4-(diethylamino)-2-hydroxyphenyl)(phenyl)methanone

1-(4-((4-(diethylamino)-2-methoxyphenyl)diazenyl)phenyl)ethanone

4,4'-methylenebis(N,N-diethyl-3-methoxyaniline)

Refernces

• 1、 -. "NEAR-INFRARED NERVE-SPARING FLUOROPHORES". Page/Page column 57. . Retrieved 2020/02/17.
• 2、 Arman, Hadi D.,Dang, Hang T.,Haug, Graham C.,Larionov, Oleg V.,Nguyen, Viet D.,Nguyen, Vu T.,Vuong, Ngan T. H.. "Visible-Light-Enabled Direct Decarboxylative N-Alkylation". supporting information. p. 7921 - 7927. Retrieved 2020/04/10.