Heparinsodiumsalt

Base Information

• Chemical Name: Heparinsodiumsalt
• CAS No.: 9005-49-6
• Molecular Formula: Unspecified
• Molecular Weight: 1134.93
• Hs Code.: 3001901000
• DSSTox Substance ID: DTXSID10908043
• Nikkaji Number: J1.207.985K
• Wikidata: Q76411557
• Mol file: 9005-49-6.mol

Synonyms:Heparinsodiumsalt;(2R,3S,4S,5R,6R)-6-[(2R,3S,4R,5R,6S)-4,6-dihydroxy-5-(sulfoamino)-2-(sulfooxymethyl)oxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid;Heparin derived disaccharide;76149-63-8;IdoA2S(a1-4)a-GlcNS6S;SCHEMBL4593793;DTXSID10908043;CHEBI:151315;2-O-sulfo-alpha-L-ido-hexopyranosyluronic acid-(1->4)-2-deoxy-6-O-sulfo-2-sulfoamino-alpha-D-gluco-hexopyranose;363148-40-7;4-O-(2-O-Sulfo-alpha-L-idopyranuronosyl)-2-(sulfoamino)-2-deoxy-6-O-sulfo-alpha-D-glucopyranose;alpha-D-Glucopyranose, 2-deoxy-2-(sulfoamino)-4-O-(2-O-sulfo-alpha-L-idopyranuronosyl)-, 6-(hydrogen sulfate);WURCS=2.0/2,2,1/[a2122h-1a_1-5_2*NSO/3=O/3=O_6*OSO/3=O/3=O][a2121A-1a_1-5_2*OSO/3=O/3=O]/1-2/a4-b1

Chemical Property of Heparinsodiumsalt

Chemical Property:

• Appearance/Colour: white crystalline powder
• Melting Point: 250 °C (decomp)
• Refractive Index: 1.711
• Boiling Point: 644.9oC at 760mmHg
• Flash Point: 343.8oC
• PSA: 652.39000
• Density: 2.13g/cm³
• LogP: -4.52610
• Solubility.: H2O: 50 mg/mL, clear, faintly yellow
• XLogP3: -6
• Hydrogen Bond Donor Count: 9
• Hydrogen Bond Acceptor Count: 21
• Rotatable Bond Count: 10
• Exact Mass: 594.98190558
• Heavy Atom Count: 36
• Complexity: 1090

Purity/Quality:

99.9% ^*data from raw suppliers

Heparin ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C1C(C(C(C(O1)O)NS(=O)(=O)O)O)OC2C(C(C(C(O2)C(=O)O)O)O)OS(=O)(=O)O)OS(=O)(=O)O
• Isomeric SMILES: C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)NS(=O)(=O)O)O)O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](O2)C(=O)O)O)O)OS(=O)(=O)O)OS(=O)(=O)O
• Description: Parnaparin sodium is a low molecular weight heparin obtained from bovine mucosal heparin by chemical depolymerization. It has more potent antithrombotic and profibrinolytic activity than heparin evidenced by its higher activity in inhibiting factor Xa and in reducing plasma activity of platelet activator inhibitor. It is effective in improving the venous blood outflow of lower limbs in deep vein thrombosis (DVT) patients in addition to preventing DVT following orthopaedic surgery, reportedly without causing bleeding complications. Parnaparin has also shown efficacy in inflammatory occlusive complications of postphlebitic syndrome and in acute myocardial infarction.
• Uses: Medicine (anticoagulant), biochemical research, rodenticides.
• Therapeutic Function: Anticoagulant
• Biological Functions: Heparin (heparin sodium) is a mixture of highly electronegative acidic mucopolysaccharides that contain numerous N- and O-sulfate linkages. It is produced by and can be released from mast cells and is abundant in liver, lungs, and intestines.
• Clinical Use: #N/A
• Drug interactions: Potentially hazardous interactions with other drugs Analgesics: increased risk of bleeding with NSAIDs - avoid concomitant use with IV diclofenac; increased risk of haemorrhage with ketorolac - avoid. Nitrates: anticoagulant effect reduced by infusions of glyceryl trinitrate. Use with care in patients receiving oral anticoagulants, platelet aggregation inhibitors, aspirin or dextran.

Technology Process of Heparinsodiumsalt

There total 2 articles about Heparinsodiumsalt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

heparin sodium salt (9041-08-1) → heparin (9005-49-6)

Guidance literature:

With Amberlit IR-124; In water; at 36.85 ℃; Further Variations:; Reagents; Equilibrium constant; Kinetics;

DOI:10.1016/j.carres.2005.02.011

Reference yield:

→ heparin (9005-49-6)

Guidance literature:

Reference yield:

heparin (9005-49-6) → D-Galactose (10257-28-0) + 2-deoxy-2-amino glucose (90-76-6,90-77-7,530-23-4,579-32-8,579-33-9,643-68-5,2596-19-2,6490-68-2,6490-70-6,6490-72-8,6490-73-9,6490-74-0,14196-84-0,14196-86-2,14257-69-3,58381-21-8) + D-glucuronic acid (6556-12-3,489-91-8,528-16-5,552-12-5,577-46-8,643-33-4,2240-07-5,6294-16-2,10133-02-5,18402-78-3,18968-14-4,21179-08-8,23018-83-9,33599-45-0,33599-46-1,46171-67-9,46171-69-1,46172-26-3,70021-34-0,71031-08-8,104195-06-4,106499-29-0,124817-72-7) + D-galactosamine (90-76-6,90-77-7,530-23-4,579-32-8,579-33-9,643-68-5,2596-19-2,6490-68-2,6490-70-6,6490-72-8,6490-73-9,6490-74-0,14196-84-0,14196-86-2,14257-69-3,58381-21-8) + C5H10O6 + C12H21NO11 + C11H21NO10

Guidance literature:

With trifluoroacetic acid; at 110 ℃; for 3h;

DOI:10.1016/j.ab.2014.07.021

upstream raw materials:

heparin sodium salt

Downstream raw materials:

C₁₂H₂₀O₁₄S

C₁₂H₂₀O₁₇S₂

C₁₂H₂₀O₁₇S₂

C₁₂H₂₀O₁₄S

Refernces

• 1、 -. "ANTI-AMNESIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM". . . Retrieved 2009/12/23.
• 2、 -. "Keratinocyte growth factor-2 formulations". . . Retrieved 2008/06/13.