Timoprazole

Base Information

• Chemical Name: Timoprazole
• CAS No.: 57237-97-5
• Molecular Formula: C13H11 N3 O S
• Molecular Weight: 257.316
• Mol file: 57237-97-5.mol

Synonyms:2-(2-Pyridylmethylsulfinyl)benzimidazole;2-Benzimidazolyl 2-pyridylmethyl sulfoxide; H 83/69; Timoprazole

Chemical Property of Timoprazole

Chemical Property:

• Vapor Pressure: 9.65E-12mmHg at 25°C
• Boiling Point: 540.3°Cat760mmHg
• PKA: pKa 3.12 (Uncertain);8.82 (Uncertain)
• Flash Point: 280.6°C
• PSA: 77.85000
• Density: 1.45g/cm³
• LogP: 3.13140

Purity/Quality:

99% ^*data from raw suppliers

TIMOPRAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Timoprazole

There total 8 articles about Timoprazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-{[(pyridin-2-yl)methyl]thio}-1H-benzimidazole (23593-22-8) → timoprazole (57237-97-5)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 1.) -10 deg C 15 min, 2.) RT 1 h;

Reference yield: 39.0%

2-(Pyridin-2-ylmethylsulfanyl)-1H-benzoimidazole; hydrochloride (23593-23-9,57258-32-9,65680-57-1) → timoprazole (57237-97-5)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 0.166667h;

Reference yield:

2-chloromethylpyridine (4377-33-7) + Benzimidazol-2-thiol (134469-07-1) → timoprazole (57237-97-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / 1,2-dimethoxyethane / 8 h / 50 °C

2: 3-chloro-benzenecarboperoxoic acid / chloroform / 0 °C

With 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; In 1,2-dimethoxyethane; chloroform;

DOI:10.3390/molecules25173979

upstream raw materials:

2-<(2-pyridinylmethyl)thio>-1-(morpholinylmethyl)benzimidazole

2-(Pyridin-2-ylmethylsulfanyl)-1H-benzoimidazole; hydrochloride

2-{[(pyridin-2-yl)methyl]thio}-1H-benzimidazole

2-chloromethylpyridine hydrochloride

Downstream raw materials:

(benzimidazol-2-yl) benzyl sulfoxide

2-Benzenesulfinyl-1H-benzoimidazole

2-(phenylsulfanyl)-1H-benzimidazole

2-(ethylsulfanyl)-1H-benzimidazole

Refernces

• 1、 -. "Process for the preparation of organic compounds containing a sulfinyl or sulfonyl group in the presence of epsilon-phthalimidoperhexanoic acid". Page 4. . Retrieved 2008/06/13.
• 2、 Quelever, Gilles,Sturtz, Georges. "Synthesis of New 1-Carbamoyl-5-fluorouracil Conjugates, Derived from Omeprazole and Cimetidine". . p. 817 - 822. Retrieved 2007/10/03.