1-(isoquinolin-1-yl)-1-phenylethanol

Base Information

• Chemical Name: 1-(isoquinolin-1-yl)-1-phenylethanol
• CAS No.: 5467-83-4
• Molecular Formula: C17H15NO
• Molecular Weight: 249.3071
• Mol file: 5467-83-4.mol

Synonyms:

Chemical Property of 1-(isoquinolin-1-yl)-1-phenylethanol

Chemical Property:

• Vapor Pressure: 2.17E-08mmHg at 25°C
• Boiling Point: 436.5°Cat760mmHg
• Flash Point: 217.8°C
• Density: 1.181g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(isoquinolin-1-yl)-1-phenylethanol

There total 8 articles about 1-(isoquinolin-1-yl)-1-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C17H15NO (1394906-08-1) → 1-[1]isoquinolyl-1-phenyl-ethanol (5467-83-4)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.3987/COM-12-12492

Reference yield:

1-isoquinolinecarboxylic acid (486-73-7) → 1-[1]isoquinolyl-1-phenyl-ethanol (5467-83-4)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanolic H₂SO₄

2: sodium ethylate; toluene / und anschliessend mit wss. Salzsaeure

3: diethyl ether / und Behandeln des Reaktionsprodukts mit wss.Ammoniumchlorid-Loesung

With diethyl ether; sulfuric acid; sodium ethanolate; toluene;

DOI:10.1021/ja01224a015

Reference yield:

ethyl isoquinoline-1-carboxylate (50458-78-1) → 1-[1]isoquinolyl-1-phenyl-ethanol (5467-83-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium ethylate; toluene / und anschliessend mit wss. Salzsaeure

2: diethyl ether / und Behandeln des Reaktionsprodukts mit wss.Ammoniumchlorid-Loesung

With diethyl ether; sodium ethanolate; toluene;

DOI:10.1021/ja01224a015

upstream raw materials:

1-acetylisoquinoline

1-isoquinolinecarboxylic acid

acetophenone

2-benzoyl-1-cyano-1,2-dihydroisoquinoline

Refernces