Thiazolo[4,5-b]pyridine-6-carboxylic acid, 2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]-4-ethyl-4,7-dihydro-7- oxo-

Base Information

• Chemical Name: Thiazolo[4,5-b]pyridine-6-carboxylic acid, 2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]-4-ethyl-4,7-dihydro-7- oxo-
• CAS No.: 94507-70-7
• Molecular Formula: C₂₆H₂₅ClN₄O₃S
• Molecular Weight: 509.029
• Mol file: 94507-70-7.mol

Synonyms:

Chemical Property of Thiazolo[4,5-b]pyridine-6-carboxylic acid, 2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]-4-ethyl-4,7-dihydro-7- oxo-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thiazolo[4,5-b]pyridine-6-carboxylic acid, 2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]-4-ethyl-4,7-dihydro-7- oxo-

There total 6 articles about Thiazolo[4,5-b]pyridine-6-carboxylic acid, 2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]-4-ethyl-4,7-dihydro-7- oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-(4-chlorobenzhydryl)piperazine (303-26-4) + 4-Ethyl-4,7-dihydro-2-methylsulfonyl-7-oxothiazolo<4,5-b>pyridine-6-carboxylic Acid (94507-77-4) → 4-Ethyl-4,7-dihydro-2-<4-(4-chlorobenzhydryl)piperazinyl>-7-oxothiazolo<4,5-b>pyridine-6-carboxylic Acid (94507-70-7)

Guidance literature:

In ethanol; for 0.25h; Heating;

DOI:10.1002/jhet.5570210522

Reference yield:

4-Ethyl-4,7-dihydro-2-methylthio-7-oxothiazolo<4,5-b>pyridine-6-carboxylic Acid (65095-79-6) → 4-Ethyl-4,7-dihydro-2-<4-(4-chlorobenzhydryl)piperazinyl>-7-oxothiazolo<4,5-b>pyridine-6-carboxylic Acid (94507-70-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / 85percent m-Chloroperoxybenzoic Acid / CHCl₃ / 1 h / Heating

2: 80 percent / ethanol / 0.25 h / Heating

With 3-chloro-benzenecarboperoxoic acid; In ethanol; chloroform;

DOI:10.1002/jhet.5570210522

Reference yield:

Ethyl 7-Hydroxy-2-methylthiothiazolo<4,5-b>pyridine-6-carboxylate (65095-77-4) → 4-Ethyl-4,7-dihydro-2-<4-(4-chlorobenzhydryl)piperazinyl>-7-oxothiazolo<4,5-b>pyridine-6-carboxylic Acid (94507-70-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / Sodium hydride / dimethylformamide / 3 h / 80 - 100 °C

2: 85 percent / 1N aq. HCl, 90percent acetic acid / 3 h / Heating

3: 94 percent / 85percent m-Chloroperoxybenzoic Acid / CHCl₃ / 1 h / Heating

4: 80 percent / ethanol / 0.25 h / Heating

With hydrogenchloride; sodium hydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; In ethanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570210522

upstream raw materials:

N-(4-chlorobenzhydryl)piperazine

4-Ethyl-4,7-dihydro-2-methylsulfonyl-7-oxothiazolo<4,5-b>pyridine-6-carboxylic Acid

4-Ethyl-4,7-dihydro-2-methylthio-7-oxothiazolo<4,5-b>pyridine-6-carboxylic Acid

Ethyl 7-Hydroxy-2-methylthiothiazolo<4,5-b>pyridine-6-carboxylate

Refernces