5-CHLOROISOQUINOLINE

Base Information

• Chemical Name: 5-CHLOROISOQUINOLINE
• CAS No.: 5430-45-5
• Molecular Formula: C9H6 Cl N
• Molecular Weight: 163.606
• Hs Code.: 2933499090
• Mol file: 5430-45-5.mol

Synonyms:5-Chloroisoquinoline;NSC 13799

Chemical Property of 5-CHLOROISOQUINOLINE

Chemical Property:

• Appearance/Colour: White Solid
• Vapor Pressure: 0.00382mmHg at 25°C
• Melting Point: 72-73°C
• Boiling Point: 289.5 °C at 760 mmHg
• Flash Point: 156.4 °C
• PSA: 12.89000
• Density: 1.27 g/cm³
• LogP: 2.88820
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

5-Chloroisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 5-CHLOROISOQUINOLINE

There total 8 articles about 5-CHLOROISOQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

isoquinolin-5-ylamine (1125-60-6) → 5-chloro-isoquinoline (5430-45-5)

Guidance literature:

isoquinolin-5-ylamine; With hydrogenchloride; sodium nitrite; at 0 - 5 ℃;

With copper(l) chloride;

DOI:10.1021/jm049025p

Reference yield: 45.0%

isoquinoline (119-65-3) → 5-chloro-isoquinoline (5430-45-5) + 5,8-dichloroisoquinoline (73075-59-9)

Guidance literature:

With trichloroisocyanuric acid; sulfuric acid; at 0 - 10 ℃; for 24h;

DOI:10.1055/s-0037-1609153

Reference yield:

(3-chloro-benzylidenamino)-acetaldehyde diethylacetal → 7-chloroisoquinoline (34784-06-0) + 5-chloro-isoquinoline (5430-45-5)

Guidance literature:

With sulfuric acid; phosphorus pentoxide; at 160 ℃;

upstream raw materials:

sulfuric acid

isoquinolin-5-ylamine

5-nitroisoquinoline

m-Chlorobenzaldehyde

Downstream raw materials:

2-benzoyl-5-chloro-1-cyano-1,2-dihydroisoquinoline

5-chloro-1-(3,4-dimethoxybenzyl)-isoquinoline

8-bromo-5-chloroisoquinoline

5-chloro-8-phenylisoquinoline

Refernces

• 1、 Graulich, Amaury,Scuvée-Moreau, Jacqueline,Seutin, Vincent,Liégeois, Jean-Fran?ois. "Synthesis and radioligand binding studies of C-5- and C-8-substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums as SK channel blockers related to N-methyl-laudanosine and N-methyl-noscapine". . p. 4972 - 4982. Retrieved 2007/10/03.