(R)-1-Benzyl-3-Hydroxy Pyridine

Base Information

• Chemical Name: (R)-1-Benzyl-3-Hydroxy Pyridine
• CAS No.: 94923-25-8
• Molecular Formula: C12H13NO
• Molecular Weight: 187.241
• Mol file: 94923-25-8.mol

Synonyms:1-Benzyl-1H-pyrrolo[3,2-c]pyridin-4(5H)-one;1-benzyl-1,6-dihydro-3(2H)-pyridinone;1-benzyl-1,5-dihydro-pyrrolo[3,2-c]pyridin-4-one;Benzyl-1-dihydro-4,5-oxo-4-aza-5-indol;1-Benzyl-4-oxo-4,5-dihydro-pyrrolo<3,2-c>pyridin;1-Benzyl-4-hydroxy-5-azaindole;1-benzyl-1,2,3,6-tetrahydropyridin-4-en-3-one;1-benzyl-4,5-dihydro-4-oxopyrrolo<3,2-c>pyridine;1-Benzyl-4.5-dihydro-4-oxo-5-aza-indol;

Chemical Property of (R)-1-Benzyl-3-Hydroxy Pyridine

Chemical Property:

• Boiling Point: 309.3±31.0 °C(Predicted)
• PKA: 4.59±0.20(Predicted)
• PSA: 23.47000
• Density: 1.130±0.06 g/cm3(Predicted)
• LogP: 2.39570

Purity/Quality:

98%Min ^*data from raw suppliers

1-benzyl-1,2-dihydropyridin-3(6H)-one 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-Benzyl-3-Hydroxy Pyridine

There total 2 articles about (R)-1-Benzyl-3-Hydroxy Pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

1-benzyl-3-methoxy-5-oxo-3,4-dehydropiperidine (50720-06-4) → 1-benzyl-1,2,3,6-tetrahydropyridin-4-en-3-one (94923-25-8)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 2h; Ambient temperature;

Reference yield:

1-(benzyl)piperidin-3,5-dione (50866-56-3) → 1-benzyl-1,2,3,6-tetrahydropyridin-4-en-3-one (94923-25-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / HCl(g)

2: 71 percent / NaBH₄ / ethanol / 2 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; In ethanol;

Reference yield: 93.0%

benzyl chloroformate (501-53-1,94274-21-2) + 1-benzyl-1,2,3,6-tetrahydropyridin-4-en-3-one (94923-25-8) → benzyl 1,6-dihydro-3(2H)-oxopyridine-1-carboxylate (82644-99-3)

Guidance literature:

In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jo0007128

upstream raw materials:

1-benzyl-3-methoxy-5-oxo-3,4-dehydropiperidine

1-(benzyl)piperidin-3,5-dione

Downstream raw materials:

benzyl 1,6-dihydro-3(2H)-oxopyridine-1-carboxylate

1-methoxycarbonyl-1,2,3,6-tetrahydropyridin-4-en-3-one

1-benzyl-4-(4-fluoro-phenyl)-1,6-dihydro-2H-pyridin-3-one

4-(4-fluoro-phenyl)-3-hydroxy-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester

Refernces