4-CHLORO (1H)INDAZOLE

Base Information

• Chemical Name: 4-CHLORO (1H)INDAZOLE
• CAS No.: 13096-96-3
• Molecular Formula: C7H5ClN2
• Molecular Weight: 152.583
• Hs Code.: 2933990090
• Mol file: 13096-96-3.mol

Synonyms:4-Chloroindazole;NSC 694315;

Chemical Property of 4-CHLORO (1H)INDAZOLE

Chemical Property:

• Vapor Pressure: 0.00116mmHg at 25°C
• Melting Point: 155-157 °C
• Refractive Index: 1.703
• Boiling Point: 309.5 °C at 760 mmHg
• Flash Point: 169.9 °C
• PSA: 28.68000
• Density: 1.425 g/cm³
• LogP: 2.21630
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Chloro-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25-36
• Safety Statements: 45-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO (1H)INDAZOLE

There total 9 articles about 4-CHLORO (1H)INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-chloro-2-methylbenzenamine (87-60-5) → 4-chloro-1H-indazole (13096-96-3)

Guidance literature:

3-chloro-2-methylbenzenamine; With potassium acetate; acetic anhydride; In chloroform; at 0 - 25 ℃; for 1.03333h;

With isopentyl nitrite; In chloroform; at 60 ℃;

Reference yield: 82.0%

2-chloro-6-fluorobenzaldehyde (387-45-1) → 2-chloro-6-fluorotoluene (443-83-4) + 4-chloro-1H-indazole (13096-96-3)

Guidance literature:

With hydrazine hydrate; In 1,2-dimethoxyethane; for 15h; Heating;

DOI:10.1021/jo0613784

Reference yield: 70.0%

2-chloro-6-fluorobenzaldehyde (387-45-1) → 4-chloro-1H-indazole (13096-96-3)

Guidance literature:

upstream raw materials:

N-(3-chloro-2-methylphenyl)benzamide

N-acetyl-4-chloro-1H-indazole

3-chloro-2-methylbenzenamine

cis-nitrous acid

Downstream raw materials:

N-acetyl-4-chloro-1H-indazole

Refernces

• 1、 Boulouard, Michel,Schumann-Bard, Pascale,Butt-Gueulle, Sabrina,Lohou, Elodie,Stiebing, Silvia,Collot, Valerie,Rault, Sylvain. "4-Substituted indazoles as new inhibitors of neuronal nitric oxide synthase". . p. 3177 - 3180. Retrieved 2007.
• 2、 Bream, Robert N.,Clark, Hugh,Edney, Dean,Harsanyi, Antal,Hayler, John,Ironmonger, Alan,Mc Cleary, Nadine,Phillips, Natalie,Priestley, Catherine,Roberts, Alastair,Rushworth, Philip,Szeto, Peter,Webb, Michael R.,Wheelhouse, Katherine. "Application of C-H Functionalization in the Development of a Concise and Convergent Route to the Phosphatidylinositol-3-kinase Delta Inhibitor Nemiralisib". supporting information. p. 529 - 540. Retrieved 2021/03/01.
• 3、 -. "PROCESSES TO MAKE INDAZOLE DERIVATIVES". Page/Page column 22. . Retrieved 2016/12/22.