beta-Lumicolchicine

Base Information

• Chemical Name: beta-Lumicolchicine
• CAS No.: 6901-14-0
• Molecular Formula: C22H25 N O6
• Molecular Weight: 399.444
• European Community (EC) Number: 230-008-1,230-009-7
• DSSTox Substance ID: DTXSID901102123
• Nikkaji Number: J15.662K
• Wikidata: Q105288000
• Mol file: 6901-14-0.mol

Synonyms:beta Lumicolchicine;beta-Lumicolchicine;gamma Lumicolchicine;gamma-Lumicolchicine;Lumicolchicines

Chemical Property of beta-Lumicolchicine

Chemical Property:

• Vapor Pressure: 1.88E-15mmHg at 25°C
• Melting Point: 268°C
• Boiling Point: 623.2°C at 760 mmHg
• Flash Point: 330.7°C
• PSA: 83.09000
• Density: 1.3g/cm³
• LogP: 2.66680
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly, Heated)
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 399.16818752
• Heavy Atom Count: 29
• Complexity: 758

Purity/Quality:

98%min ^*data from raw suppliers

γ-Lumi(-)-Colchicine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1CCC2=CC(=C(C(=C2C3=C1C4C3C=C(C4=O)OC)OC)OC)OC
• Isomeric SMILES: CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=C1[C@@H]4[C@H]3C=C(C4=O)OC)OC)OC)OC
• Uses: γ-Lumi (-)-Colchicine is a component of Colchicum species of plants and an electrocyclization product of Colchicine (C640000), an antimitotic agent that disrupts microtubules polymerization.

Technology Process of beta-Lumicolchicine

There total 5 articles about beta-Lumicolchicine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

colchicine (64-86-8,54192-66-4) → β-lumicolchicine (6901-14-0) + lumicolchicine (6901-13-9)

Guidance literature:

With water; Irradiation.weiteres Nebenprodukt: (+)-β-Lumicolchicin; Sonnenlicht;

DOI:10.1039/jr9550003864

Reference yield:

methanol (67-56-1) + colchicine (64-86-8,54192-66-4) → (+)-α-lumicolchicine (7183-82-6) + β-lumicolchicine (6901-14-0) + lumicolchicine (6901-13-9)

Guidance literature:

Sonnenlicht;

DOI:10.1039/jr9550003864

Reference yield:

colchicine (64-86-8,54192-66-4) + water (7732-18-5) → (+)-α-lumicolchicine (7183-82-6) + β-lumicolchicine (6901-14-0) + lumicolchicine (6901-13-9)

Guidance literature:

UV-Licht <γ: >334 nm>;

upstream raw materials:

methanol

colchicine

water

Refernces

• 1、 Bussotti, Laura,Cacelli, Ivo,D'Auria, Maurizio,Foggi, Paolo,Lesma, Giordano,Silvani, Alessandra,Villani, Vincenzo. "Photochemical Isomerization of Colchicine and Thiocolchicine". . p. 9079 - 9085. Retrieved 2007/10/03.