Technology Process of Benzeneacetic acid, a-(formyloxy)-, (S)-
There total 1 articles about Benzeneacetic acid, a-(formyloxy)-, (S)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 6 steps
1: thionyl chloride, dimethylformamide / Heating
2: 97 percent / triethylamine / CH2Cl2 / 0.5 h
3: 86 percent / NaHCO3 / H2O / 6 h / Ambient temperature
4: 40 percent / triethylamine / dimethylformamide / 16 h / Ambient temperature
5: 60 percent / lithium methoxide, t-butyl hypochlorite, glacial acetic acid / tetrahydrofuran / 1.) -72 deg C, 5 min, 2.) -70 deg C, 30 min, 3,) -70 deg C --> room temperature
6: 84 percent / H2 / Pd/C / methanol; H2O
With
thionyl chloride; tert-butylhypochlorite; lithium methanolate; hydrogen; sodium hydrogencarbonate; acetic acid; triethylamine; N,N-dimethyl-formamide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: thionyl chloride, dimethylformamide / Heating
2: 2.) KHCO3 / 1.) acetone, water, room temperature, 2.) methanol, room temperature
3: KHCO3 / dimethylformamide / 5 h / Ambient temperature
4: 77 percent / lithium methoxide, t-butyl hypochlorite, glacial acetic acid / tetrahydrofuran / 1.) -72 deg C, 20 min, 2.) -70 deg C, 30 min, 3.) -70 deg C --> room temperature
5: 90 percent / H2 / Pd/C / ethyl acetate; methanol / 1.5 h / Ambient temperature
With
thionyl chloride; tert-butylhypochlorite; lithium methanolate; hydrogen; potassium hydrogencarbonate; acetic acid; N,N-dimethyl-formamide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;