1,3-BENZODIOXOL-5-YL 2-PROPYNYL ETHER

Base Information

• Chemical Name: 1,3-BENZODIOXOL-5-YL 2-PROPYNYL ETHER
• CAS No.: 19947-80-9
• Molecular Formula: C10H8O3
• Molecular Weight: 176.172
• Hs Code.: 2932990090
• Mol file: 19947-80-9.mol

Synonyms:sesamol propargyl ether;5-(propargyloxy)-benzo[1,3]dioxole;5-(prop-2-ynyloxy)benzo[d][1,3]dioxole;

Chemical Property of 1,3-BENZODIOXOL-5-YL 2-PROPYNYL ETHER

Chemical Property:

• PSA: 27.69000
• LogP: 1.42730

Purity/Quality:

99% ^*data from raw suppliers

5-(Prop-2-yn-1-yloxy)-2H-1,3-benzodioxole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-BENZODIOXOL-5-YL 2-PROPYNYL ETHER

There total 3 articles about 1,3-BENZODIOXOL-5-YL 2-PROPYNYL ETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Sesamol (533-31-3) + propargyl bromide (106-96-7) → 5-(prop-2-yn-1-yloxy)benzo[d][1,3]dioxole (19947-80-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; toluene; at 20 ℃; for 7h; Inert atmosphere;

DOI:10.1016/j.tet.2015.06.075

Reference yield: 85.0%

Sesamol (533-31-3) + dipropargyl ether (6921-27-3) → 5-(prop-2-yn-1-yloxy)benzo[d][1,3]dioxole (19947-80-9)

Guidance literature:

With potassium carbonate; In acetone; toluene; at 20 ℃;

DOI:10.1021/acs.orglett.9b03999

Reference yield:

→ 5-(prop-2-yn-1-yloxy)benzo[d][1,3]dioxole (19947-80-9)

Guidance literature:

DOI:10.1021/jf60167a033

upstream raw materials:

Sesamol

propargyl bromide

dipropargyl ether

Downstream raw materials:

4β-[(4-(benzo[d][1,3]dioxol-5-yloxy)methyl)-1H-1,2,3-triazol-1-yl]-4-desoxypodophyllotoxin

(6-hydroxybenzo[d][1,3]dioxol-5-yl)(phenyl)methanone

Refernces

• 1、 Tian, Jie-Sheng,He, Yu,Gao, Zhi-Yuan,Liu, Xu,Dong, Shuang-Feng,Wu, Peng,Loh, Teck-Peng. "Water-Tolerant ortho-Acylation of Phenols". supporting information. p. 6594 - 6598. Retrieved 2021/09/02.
• 2、 Ashooriha, Morteza,Emami, Saeed,Kardan, Mostafa,Khoshneviszadeh, Mahsima,Khoshneviszadeh, Mehdi,Rafiei, Alireza,Yazdian-Robati, Rezvan. "Kojic acid–natural product conjugates as mushroom tyrosinase inhibitors". . . Retrieved 2020/07/10.