Benzenemethanamine,3-(trifluoromethyl)-, hydrochloride (1:1)

Base Information

• Chemical Name: Benzenemethanamine,3-(trifluoromethyl)-, hydrochloride (1:1)
• CAS No.: 2944-96-9
• Molecular Formula: C8H8 F3 N . Cl H
• Molecular Weight: 211.614
• Mol file: 2944-96-9.mol

Synonyms:Benzenemethanamine,3-(trifluoromethyl)-, hydrochloride (9CI); Benzylamine, m-(trifluoromethyl)-,hydrochloride (7CI,8CI)

Chemical Property of Benzenemethanamine,3-(trifluoromethyl)-, hydrochloride (1:1)

Chemical Property:

• Boiling Point: 180.6°Cat760mmHg
• Flash Point: 71.1°C
• Density: 1.225g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanamine,3-(trifluoromethyl)-, hydrochloride (1:1)

There total 5 articles about Benzenemethanamine,3-(trifluoromethyl)-, hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-trifluoromethylbenzonitrile (368-77-4) → (3-(trifluoromethyl)phenyl)methanamine hydrochloride (2944-96-9)

Guidance literature:

3-trifluoromethylbenzonitrile; With [2,6-η6:η1-bis(2,4,6-trimethylphenyl)phenylthiolato]triethylphosphineruthenium(II)tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; diethylphenylsilane; at 20 ℃; for 18h; Glovebox; Inert atmosphere;

With hydrogenchloride; In diethyl ether; at 20 ℃; for 1h; Glovebox; Inert atmosphere;

DOI:10.1055/s-0036-1588441

Reference yield: 78.0%

1‐(azidomethyl)‐3‐(trifluoromethyl)benzene (620533-90-6) → (3-(trifluoromethyl)phenyl)methanamine hydrochloride (2944-96-9)

Guidance literature:

1‐(azidomethyl)‐3‐(trifluoromethyl)benzene; With 1,3-diphenyl-disiloxane; triphenylphosphine; at 20 ℃; for 24h;

With water;

With hydrogenchloride; In 1,4-dioxane; chemoselective reaction;

DOI:10.1021/acs.joc.9b00831

Reference yield: 77.0%

3-trifluoromethylbenzamide (1801-10-1) → (3-(trifluoromethyl)phenyl)methanamine hydrochloride (2944-96-9)

Guidance literature:

3-trifluoromethylbenzamide; With [(aNHC)KN(SiMe₃)₂]₂; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In toluene; at 40 ℃; for 12h; Inert atmosphere; Glovebox; Schlenk technique;

With water; sodium hydroxide; In diethyl ether; toluene; at 40 ℃; for 1h; Inert atmosphere; Glovebox; Schlenk technique;

With hydrogenchloride; In diethyl ether; water; Inert atmosphere; Glovebox; Schlenk technique;

DOI:10.1039/c9sc05953a

upstream raw materials:

3-trifluoromethylbenzonitrile

1‐(azidomethyl)‐3‐(trifluoromethyl)benzene

3-trifluoromethylbenzamide

3-(TRIFLUOROMETHYL)BENZYLAMINE

Refernces

• 1、 Ganguli, Kasturi,Mandal, Adarsha,Sarkar, Bidisha,Kundu, Sabuj. "Benzimidazole fragment containing Mn-complex catalyzed hydrosilylation of ketones and nitriles". . . Retrieved 2020/08/13.
• 2、 Lenstra, Danny C.,Wolf, Joris J.,Mecinovi?, Jasmin. "Catalytic Staudinger Reduction at Room Temperature". . p. 6536 - 6545. Retrieved 2019/05/24.