5,6-Dihydro-5-azacytidine

Base Information

• Chemical Name: 5,6-Dihydro-5-azacytidine
• CAS No.: 62488-57-7
• Molecular Formula: C8H14 N4 O5
• Molecular Weight: 246.22
• UNII: 0627D8VG1C
• DSSTox Substance ID: DTXSID7020471
• Nikkaji Number: J92.290K
• Wikidata: Q27236168
• NCI Thesaurus Code: C980
• ChEMBL ID: CHEMBL3278060
• Mol file: 62488-57-7.mol

Synonyms:5,6-dihydro-5'-azacytidine;5,6-dihydro-5-azacytidine;5,6-dihydro-5-azacytidine hydrochloride;DHAC cpd;dihydro-5-azacytidine;NSC 264880;NSC-264880

Chemical Property of 5,6-Dihydro-5-azacytidine

Chemical Property:

• Vapor Pressure: 2.09E-13mmHg at 25°C
• Boiling Point: 529.1°C at 760 mmHg
• Flash Point: 273.8°C
• PSA: 140.64000
• Density: 2.1g/cm³
• LogP: -2.87460
• XLogP3: -3
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 246.09641956
• Heavy Atom Count: 17
• Complexity: 349

Purity/Quality:

97% ^*data from raw suppliers

5,6-Dihydro-5-azacytidine >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1N=C(NC(=O)N1C2C(C(C(O2)CO)O)O)N
• Isomeric SMILES: C1N=C(NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N

Technology Process of 5,6-Dihydro-5-azacytidine

There total 2 articles about 5,6-Dihydro-5-azacytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-azacytidine (320-67-2) → 5,6-dihydro-5-azacytidine (62488-57-7)

Guidance literature:

With sodium tetrahydroborate; In water; at 20 ℃; for 1.5h;

DOI:10.1002/hlca.201800229

Reference yield:

→ 5,6-dihydro-5-azacytidine (62488-57-7)

Guidance literature:

Borkomplex 4, 6N HCl;

DOI:10.1021/jm00216a013

upstream raw materials:

5-azacytidine

Refernces